磁共振自旋锁定成像技术及其临床应用进展
Principles and clinical advances of magnetic resonance spin lock imaging
何思怡 1李博伟 2成官迅2
作者信息
- 1. 北京大学深圳医院医学影像科,深圳 518000;北京大学医学部,北京 100191
- 2. 北京大学深圳医院医学影像科,深圳 518000
- 折叠
摘要
磁共振自旋锁定成像(T1ρ成像)能在分子水平上检测组织代谢及生化信息改变,其组织定量T1ρ值较T1、T2值更能敏感的反映水分子与大分子之间的低频运动.近年来,研究者们不断改进该序列,并将其逐渐应用于骨关节炎、椎间盘退变、心肌病、肝脏纤维化、肾脏纤维化、阿尔茨海默病、多发性硬化、脑胶质瘤等多种疾病.本文将对T1ρ成像的原理、T1ρ值的影响因素、T1ρ成像的临床应用三个方面进行综述,旨在推进T1ρ技术的不断成熟,辅助指导临床诊疗.
Abstract
Magnetic resonance spin-locked imaging (T1ρ imaging) can detect changes in tissue metabolism and biochemical information at the molecular level, the T1ρ value is more sensitive than the T1 and T2 values to reflect the low-frequency movement between water molecules and macromolecules. In recent years, researchers have continuously improved this sequence and gradually applied it to a variety of diseases including osteoarthritis, intervertebral disc degeneration, cardiomyopathy, liver fibrosis, renal fibrosis, Alzheimer's disease, multiple sclerosis, and brain gliomas. This article will review the principles of T1ρ imaging, factors influencing T1ρ values, and the current research status of clinical applications of T1ρ imaging, aiming to promote the continuous maturity of T1ρ technology and assist in guiding clinical diagnosis and treatment.
关键词
骨关节炎/心肌病/肝脏纤维化/自旋锁定成像/磁共振成像Key words
osteoarthritis/cardiomyopathy/liver fibrosis/spin-lock imaging/magnetic resonance imaging引用本文复制引用
基金项目
北京大学深圳医院临床研究重点项目(LCYJZD2021004)
出版年
2024
国家科技期刊平台
NSTL
万方数据