基于rtfMRI-NF技术调控失眠障碍患者杏仁核活性对大脑度中心性的影响
Impact of regulating amygdala activity in patients with insomnia disorders using rtfMRI-NF technology on the centrality of the brain
谷宇昂 1张淼 2贾淑蕾 1孙永兵 2祁菲 3武肖玲 4邹智 3李中林 3周菁 5窦社伟 3闫峰山 3李永丽5
作者信息
- 1. 新乡医学院河南省人民医院,新乡 453003
- 2. 郑州大学人民医院,郑州 450003
- 3. 河南省人民医院医学影像科,郑州 450003
- 4. 河南省人民医院/郑州大学人民医院核医学科,郑州 450003
- 5. 郑州大学人民医院/河南省人民医院健康管理科,郑州 450003
- 折叠
摘要
目的 探讨实时功能磁共振成像神经反馈(real-time functional magnetic resonance imaging neurofeedback,rtfMRI-NF)调控失眠障碍(insomnia disorder,ID)患者杏仁核活性对大脑度中心性(degree centrality,DC)的影响.材料与方法 本研究采用rtfMRI-NF调控34例ID患者杏仁核活性,结合临床多导睡眠监测(Polysomography,PSG)、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)等量表对患者进行干预前后评估.使用配对t检验分析干预前后功能成像数据的DC值差异,并探讨调控前后DC值变化及其与临床量表等数据的相关性.结果 经rtfMRI-NF调控后,ID患者的PSQI、失眠严重程度指数(Insomnia Severity Index Scale,ISI)等量表评分均显著降低(P均<0.05).此外,右侧海马旁回的DC值显著增高(GRF校正,体素水平P<0.001,团块水平P<0.05),并与睡眠效率差值呈负相关r=-0.478,P<0.05);而右侧背外侧额上回等区域的DC值降低(GRF校正,体素水平P<0.001,团块水平P<0.05),并与干预后ISI评分呈正相关(r=0.488,P<0.05).结论 rtfMRI-NF技术可重塑ID患者特定脑区的DC值,并有效提高ID患者的睡眠质量.
Abstract
Objective:To investigate the effect of real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) on the modulation of amygdala activity and its impact on the degree centrality (DC) in the brains of patients with insomnia disorder (ID). Materials and Methods:The study applied rtfMRI-NF to modulate the amygdala activity of 34 ID patients,assessing the effects before and after treatment using Polysomnography (PSG) and the Pittsburgh Sleep Quality Index (PSQI). Paired t-tests were used to analyze the differences in DC values of brain regions before and after the intervention,exploring the changes in DC values and their correlations with clinical scale data. Results:After rtfMRI-NF modulation,significant reductions were observed in the PSQI scores and Insomnia Severity Index (ISI) among ID patients (P<0.05 for both). Furthermore,an increase in the DC value of the right parahippocampal gyrus was noted (GRF corrected,voxel-level P<0.001,cluster-level P<0.05),which negatively correlated with the change in sleep efficiency (r=-0.478,P<0.05);Conversely,a decrease in the DC value of areas such as the right dorsolateral prefrontal cortex was observed (GRF corrected,voxel-level P<0.001,cluster-level P<0.05),positively correlating with the post-intervention ISI scores (r=0.488,P<0.05). Conclusions:rtfMRI-NF can reshape the DC values of specific brain regions in ID patients and effectively improve their sleep quality.
关键词
失眠障碍/实时功能磁共振成像神经反馈/磁共振成像/静息态功能磁共振成像/杏仁核/度中心性Key words
insomnia disorder/real-time functional magnetic resonance imaging neurofeedback/magnetic resonance imaging/resting-state functional magnetic resonance imaging/amygdala/degree centrality引用本文复制引用
基金项目
国家自然科学基金(82071884)
中原科技创新领军人才项目(244200510016)
河南省医学科技攻关计划(SBGJ202302011)
河南省科技攻关计划(242102311018)
出版年
2024
国家科技期刊平台
NSTL
万方数据