Diffusion kurtosis imaging of brain white matter alteration in patients with acute mild traumatic brain injury based on the TBSS method
Objective:Diffusion kurtosis imaging (DKI) was used to study the white matter microstructure changes in mild traumatic brain injury (mTBI) patients,so as to explore the clinical application value of DKI in mTBI patients. Materials and Methods:The clinical and DKI data of 27 mTBI patients who were diagnosed in our hospital and 27 healthy control subjects matched in gender,age,and years of education recruited from January to December 2018 were analyzed. Using the tract-based spatial statistics (TBSS) method to analyze the differences in brain regions and their fractional anisotropy (FA) value,mean kurtosis (MK) value,axial kurtosis (AK) value,radial kurtosis (RK) value,and kurtosis fractional anisotropy (KFA) value between the mTBI patients subjects and the control subjects. Results:The FA value of the left superior longitudinal fasciculus (temporal part) was lower in mTBI patients (0.450±0.048) than that in the control subjects (0.480±0.028,t=-2.253,P=0.0285). The AK value of the forceps major was lower in mTBI patients (0.68±0.05) than that in the control subjects (0.72±0.05,t=-2.407,P=0.0197). The RK value of the right cingulum (hippocampus) was lower in mTBI patients (0.89±0.15) than that in the control subjects (0.99±0.18,t=-2.044,P=0.0460). The KFA values of the right anterior thalamic radiation,the right cingulum (cingulate gyrus),the right inferior fronto-occipital fasciculus,the right inferior longitudinal fasciculus,and the right superior longitudinal fasciculus (temporal part) were lower in mTBI patients[(0.49±0.19),(0.50±0.32),(0.48±0.30),(0.49±0.03),and (0.54±0.59)]than that in the control subjects[(0.51±0.13),(0.52±0.20),(0.50±0.02),(0.51±0.26),and (0.57±0.46),t=-2.15,-2.95,-2.37,-2.38,and-2.25,respectively,all P<0.05]. However,there was no statistically significant difference in MK values between the subjectss (P>0.05). Conclusions:The DKI parameter serves as a neuroimaging biomarker for assessing brain white matter alterations in patients with acute mTBI,capable of unveiling minute variations in white matter microstructure.
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