基于磁共振的局部进展期直肠癌新辅助治疗后肿瘤退缩分级评分方法应用现状
Application status of tumor regression grading method after neoadjuvant chemoradiotherapy based on magnetic resonance imaging for locally advanced rectal cancer
何宏 1陈思宇 1胡富碧1
作者信息
- 1. 成都医学院第一附属医院放射科,成都 610000
- 折叠
摘要
随着结直肠癌的发病率和死亡率在全球范围内显著上升,局部进展期直肠癌(locally advanced rectal cancer,LARC)的治疗策略引起了广泛关注.目前,新辅助治疗(neoadjuvant chemoradiotherapy,NCRT)后行全直肠系膜切除术(total mesorectal excision,TME)被推荐为LARC的标准治疗方案.尽管NCRT能显著改善预后,但LARC患者对此治疗响应存在显著差异.因此,准确评估N C RT的疗效对于临床决策和个体化医疗具有重要意义.当前的疗效评估方法包括血清肿瘤标记物、内镜、直肠腔内超声、CT/MRI等,但各有局限.近年来,磁共振肿瘤退缩分级(magnetic resonance tumor regression grade,mrTRG)系统因其无辐射、多方位成像、软组织分辨率高和动态连续观察的优点而受到关注和推荐,因此,本文旨在通过分析最新的国内外研究文献,着重探讨LARC患者NCRT后mrTRG的应用价值及其现状.
Abstract
As the incidence and mortality rates of colorectal cancer continue to rise globally,the treatment strategies for locally advanced rectal cancer (LARC) have garnered widespread attention. Currently,total mesorectal excision (TME) following neoadjuvant chemoradiotherapy (NCRT) is recommended as the standard treatment protocol for LARC. Although NCRT can significantly improve outcomes,there is notable variability in LARC patient responses to this treatment. Therefore,accurately assessing the efficacy of NCRT is crucial for clinical decision-making and personalized medicine. Current methods for assessing treatment efficacy include serum tumor markers,endoscopy,endorectal ultrasound,and CT/MRI,each with its limitations. In recent years,the magnetic resonance tumor regression grade (mrTRG) has gained attention and recommendation for its advantages of radiation-free,multi-directional imaging,high soft tissue resolution and dynamic continuous observation. Hence,this article aims to analyze the latest domestic and foreign research literature,and focus on the research value and current status of mrTRG after NCRT in LARC patients.
关键词
局部进展期直肠癌/新辅助治疗/磁共振成像/肿瘤退缩分级Key words
locally advanced rectal cancer/neoadjuvant chemoradiotherapy/magnetic resonance imaging/tumor regression grading引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据