Study on cerebral perfusion characteristic network of type 2 diabetes mellitus patients based on MR arterial spin labeling imaging
Objective:To analyze the cerebral microcirculation blood flow perfusion and perfusion patterns in patients with type 2 diabetes mellitus (T2DM) by using MR arterial spin labeling (ASL),and to analyze the correlation between these changes and biochemical indexes. Materials and Methods:Twenty-eight patients who met our T2DM diagnostic criteria and 26 healthy control (HC) were selected in this study. We conducted ASL,principal component analysis,and calculated the cerebral blood flow (CBF) and perfusion feature network on subjects. Results:Compared with HC group,the perfusion areas including bilateral paracentral lobules,left supplementary motor area,the middle bilateral gyrus cinguli,left opercular part of the inferior frontal gyrus,left middle temporal gyrus,and left inferior temporal gyrus in diabetic patients were significantly lower (P<0.05,GRF adjusted). The ratios of the variance components of the two disease-related perfusion networks to the total variance were 17.6％ and 11.7％ (95％ confidence interval),and they were statistically significant. The first perfusion network characteristic expression value was significantly positively correlated with fasting blood glucose (r=0.32,P=0.001),and the extracted CBF of the diabetic group using the second perfusion characteristic network as a template was negatively correlated with the patient's fasting blood glucose (r=0.12,P=0.03). Conclusions:The diabetic patients had low regional cerebral blood flow. Principal component-based perfusion characteristics can identify patients with diabetes. The changes in perfusion patterns reflected the remodeling of cerebral blood flow perfusion,which had more important value and significance for the early diagnosis and intervention of diabetic microangiopathy.
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