Quantitative evaluation of liver fibrosis by MRE and Gd-EOB-DTPA-enhanced T1 mapping magnetic resonance imaging in a rabbit model
Objective:To compare the accuracy of MR elastography (MRE) and Gd-EOB-DTPA-enhanced T1 mapping in the quantitative evaluation of liver fibrosis (LF) staging. Materials and Methods:One hundred and twenty rabbits were randomly divided into control group (n=20),which were injected subcutaneously with normal saline solution,and LF group (n=100),which were received 50％ (carbon tetrachloride) CCl4 oil solution. The control group (n=5) and LF group (n=25) underwent MRI axial scan,T1WI,MRE,Gd-EOB-DTPA-enhanced T1 mapping at the end of the 4th,5th,6th,15th week. The pathological LF staging was based on Scheuer staging system. The quantitative parameter included liver stiffness (LS),pre-and post-contrast T1 values of the liver (T1native and T120min),the reduction rate of T1 relaxation time (ΔT120min) and the increase in T1 relaxation rate (ΔR120min),were compared the differences by one-way ANOVA analysis. Spearman correlation coefficients,Receiver operating characteristic (ROC) analysis was used respectively to determine the correlation and diagnostic performance between quantitative parameters and pathological LF staging. Results:A total of 96 rabbits were included in F0 (n=15),F1 (n=22),F2 (n=22),F3 (n=18) and F4 (n=19). LS,T1native,T120min,ΔT120min,ΔR120min showed significant differences among all LF staging (P<0.05). There were correlation between LS,T1native,T120min,ΔT120min,ΔR120min and LF stage (r=0.935,0.559,0.770,−0.418 −0.686,P<0.001),respectively. LS exhibited the largest area under the curve (AUC),which were 0.988,0.979,1.000,0.995 for F0 vs. F1～F4,F0 vs. F1～F2,F0 vs. F3～F4,F1～F2 vs. F3～F4,respectively. Secondly,the AUC of T120min were 0.914,0.852,0.987,and 0.896,respectively. Conclusions:In the early quantitative evaluation of LF staging,MRE and Gd-EOB-DTPA enhanced T1 mapping had demonstrated significant diagnostic value,with MRE outperforming Gd-EOB-DTPA enhanced T1 mapping.
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