Prenatal MRI quantified the deep gray matter volume of the fetal brain in tetralogy of Fallot
Objective:To quantitatively evaluate the difference of deep gray matter (DGM) volume in fetuses with tetralogy of Fallot (TOF) compared with normal fetuses by prenatal MRI. Materials and Methods:Sixty single pregnant women with gestational age (GA) of 19-33 weeks received prenatal fetal MRI examination,of which 30 fetuses with TOF had an average GA of (25.30±3.65) weeks,including 15 cases GA<26 weeks and 15 cases GA≥26 weeks. The average GA (25.83±3.98) weeks was normal in 30 cases (control group),including 15 cases GA<26 weeks and 15 cases GA≥26 weeks. Fetal MRI was collected using single-shot turbo spin echo (SSTSE) sequence. After image post-processing,the brain was manually divided and the three-dimensional volume of DGM on both sides of the fetal brain was measured. The DGM volume and GA of fetal brain were analyzed by regression,and the difference of DGM volume and the symmetry of left and right DGM volume between the two groups were compared. Results:There was no significant difference in DGM volume between the two groups. The fetal DGM volume of GA<26 weeks TOF group was lower than that of normal control group (t=2.90,P=0.007). DGM volume of the TOF group with GA≥26 weeks was also decreased compared with the normal control group (t=2.11,P=0.04),and the differences were statistically significant. Conclusions:Fetal DGM volume in the TOF group was different from that of normal fetuses in the first and second trimester of pregnancy,and the difference still existed in the second and third trimester of pregnancy with the rapid growth of fetal brain volume,which could provide reference for quantitative prenatal assessment of fetal brain development abnormalities of TOF.
fetusbrainmagnetic resonance imagingtetralogy of Fallotdeep gray matter volume
万方数据
维普
