Correlation of full-volume IVIM quantitative parameters with neurovascular invasion,MSI status,and Ki-67 index in rectal adenocarcinoma
Objective:To investigate the correlation of intravoxel incoherent motion (IVIM) whole-tumor volume parameter with perineural invasion (PNI),lymphovascular invasion (LVI),microsatellite instability (MSI) status and Ki-67 index in patients with rectal adenocarcinoma. Materials and Methods:Imaging and clinical data of 136 patients with rectal adenocarcinoma were retrospectively analyzed,and the true diffusion coefficient (D),pseudo-diffusion coefficient (D*),and perfusion fraction (f) of the full volume parameter of IVIM of the lesion were measured. The patients were grouped according to pathological reports of PNI status,LVI status,MSI and Ki-67 index,and the relationship between each quantitative parameter and the pathological characteristics of the tumors was analyzed by using independent samples t-test or Mann-Whitney U test. Results:The D value in the PNI-negative group of rectal adenocarcinoma[(1.174±0.164) ×10-3 mm2/s]was significantly lower than that in the positive group[(1.270±0.206) ×10-3 mm2/s](t=−3.033,P=0.003),the f value in the LVI-negative group 0.172 (0.158,0.193) was significantly lower than that in the positive group 0.188 (0.168,0.237) (Z=−2.435,P=0.015),and the f-value of the Ki-67 low expression group (0.175±0.035) was significantly lower than that of the high expression group (0.188±0.038) (t=−2.097,P=0.038). The difference in D,D*,and f values between the high microsatellite instability group and the low microsatellite instability group was not statistically significant (P>0.05). Conclusions:The full volume quantitative parameters of IVIM can reflect the pathological characteristics of rectal adenocarcinoma to a certain extent,and can be used as an important imaging index for preoperative assessment of the biological behavior of rectal adenocarcinoma.
万方数据
维普
