Research progress on the hyperarousal of insomnia treated by acupuncture based on the default mode network
The hyperarousal model is one of the important theories explaining the occurrence and maintenance of insomnia disorder (ID),yet few studies have explored the neuroimaging mechanisms of hyperarousal in ID. Research has found that ID patients often exhibit symptoms of emotional abnormalities and memory impairment,which are closely related to the functional abnormalities of the default mode network (DMN). Therefore,damage to the DMN may be one of the mechanisms of ID pathogenesis. Acupuncture may regulate the activity and functional connectivity changes of the DMN,suppress the state of cerebral hyperarousal,and thus improve ID symptoms. This article systematically reviews the mechanisms of hyperarousal in ID from molecular genetics,neuroendocrinology,heart rate variability,polysomnography,and neuroimaging perspectives. It explores the relationship between hyperarousal and the DMN,synthesizes the neuroimaging evidence of acupuncture regulation of hyperarousal in ID patients,and analyzes the connection between hyperarousal and the DMN. The aim is to provide neuroimaging evidence for the study of acupuncture intervention mechanisms in ID and to offer insights for future research directions,such as exploring from the levels of brain network connections and neuronal cells,increasing sample sizes,employing multimodal imaging techniques,and combining emerging analytical methods to more comprehensively reveal the brain effect mechanisms of acupuncture treatment for ID.
insomniahyperarousaldefault mode networkacupuncturemechanism of brain effectmagnetic resonance imaging
万方数据
维普
