膝骨关节炎(knee osteoarthritis,KOA)是一种非常普遍且容易致残的关节疾病,疼痛是其主要临床症状且病理机制复杂.随着神经影像技术在KOA疼痛研究中的应用和发展,中枢神经系统被认为在KOA疼痛的发生、发展过程中起着关键的作用.MRI技术是研究中枢神经系统的尖端技术,被广泛用于疼痛的脑中枢重塑研究,能够较为直观地显示KOA疼痛患者脑结构和功能的改变.本文将脑结构MRI(structural MRI,sMRI)及静息态功能MRI(resting-state functional MRI,rs-fMRI)技术对KOA疼痛相关研究进行综述,主要包括对KOA疼痛患者脑灰质体积和皮质厚度的改变,白质微结构完整性的异常和rs-fMRI对KOA疼痛患者的脑低频振幅(amplitude of low frequency fluctuation,ALFF)、局部一致性(regional homogeneity,ReHo)、功能连接(functional connectivity,FC)和脑网络改变方面的研究.旨在评估神经影像标志物与KOA疼痛之间的关联,丰富对KOA疼痛患者脑sMRI和rs-fMRI影像改变的认识.
Research progress on brain structure and functional magnetic resonance imaging in patients with knee osteoarthritis pain
Knee osteoarthritis (KOA) is a very common and disabling joint disease. Pain is the main clinical symptom and the pathological mechanism is complex. With the application and development of neuroimaging technology in KOA pain research,the central nervous system is considered to play a crucial role in the occurrence and development of KOA pain. MRI is a cutting-edge technology to study the central nervous system. It is widely used in the study of brain central remodeling of pain,and can more intuitively show the changes of brain structure and function in patients with KOA pain. This article reviews the research on the KOA pain using structural MRI (sMRI) and resting-state functional MRI (rs-fMRI). It mainly including changes in gray matter volume and cortical thickness in patients with KOA pain,abnormalities in white matter microstructure integrity,and rs-fMRI studies on brain low-frequency amplitude (ALFF),regional homogeneity (ReHo),functional connectivity (FC),and brain network changes in KOA pain patients. The aim of this study is to evaluate the association between neuroimaging markers and KOA pain,and to enrich the understanding of the changes of brain sMRI and rs-fMRI in patients with KOA pain.
knee osteoarthritismagnetic resonance imagingstructural magnetic resonance imagingresting-state functional magnetic resonance imagingpain
万方数据
维普
