Cerebral small vessel disease has a high incidence rate among the elderly,significantly increasing the risk of stroke and dementia. To date,there are no effective clinical or fluid biomarkers for the disease,and its diagnosis heavily relies on MRI. However,due to the limited spatial resolution of clinical imaging,it's challenging to directly assess small vessel damage. Thus,researchers primarily use imaging biomarkers reflecting cerebral parenchymal damage to evaluate small vessel injury. In recent years,with the continuous maturation of ultra-high-field (7 T) MRI technology,its application in the field of cerebral small vessel disease has become increasingly extensive. 7 T-MRI can directly assess the structure and function of small cerebral vessels and significantly enhance the detection sensitivity of minor cerebral parenchymal lesions,providing important tools for the mechanism research and precise diagnosis of cerebral small vessel disease. This article will review the recent research on cerebral small vessel disease based on 7 T-MRI and discuss potential issues and future research directions,offering references for researchers in the field.
关键词
脑小血管病/磁共振成像/超高场强/时间飞跃法磁共振血管成像/相位对比磁共振血管成像/磁敏感加权成像
Key words
cerebral small vessel disease/magnetic resonance imaging/ultra-high field/time-of-flight magnetic resonance angiography/phase-contrast magnetic resonance angiography/susceptibility-weighted imaging
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