首页|7 T磁共振成像在脑小血管病中的应用进展

7 T磁共振成像在脑小血管病中的应用进展

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脑小血管病在老年人群具有很高的发病率,可显著增加脑卒中和痴呆的发生风险.迄今为止,该疾病尚无有效的临床和体液生物标志物,诊断鉴别高度依赖于MRI.然而,由于临床影像的空间分辨率所限,脑小血管损害难以直接评价,因此研究者们主要使用一些反映脑实质损害的影像标志物来评估小血管损伤.近年来,随着超高场(7 T)MRI技术的不断成熟,其在脑小血管病领域的研究亦日趋广泛.7 T-MRI能够直接评估脑小血管结构、功能,并显著提高微小脑实质病灶的检测敏感性,为脑小血管病机制研究和精准诊断提供了重要工具.本文将回顾近年来基于7 T-MRI的脑小血管病研究,并讨论潜在的问题和未来研究方向,为相关研究工作者提供借鉴.
Advancements in the application of 7 T-MRI in cerebral small vessel disease
Cerebral small vessel disease has a high incidence rate among the elderly,significantly increasing the risk of stroke and dementia. To date,there are no effective clinical or fluid biomarkers for the disease,and its diagnosis heavily relies on MRI. However,due to the limited spatial resolution of clinical imaging,it's challenging to directly assess small vessel damage. Thus,researchers primarily use imaging biomarkers reflecting cerebral parenchymal damage to evaluate small vessel injury. In recent years,with the continuous maturation of ultra-high-field (7 T) MRI technology,its application in the field of cerebral small vessel disease has become increasingly extensive. 7 T-MRI can directly assess the structure and function of small cerebral vessels and significantly enhance the detection sensitivity of minor cerebral parenchymal lesions,providing important tools for the mechanism research and precise diagnosis of cerebral small vessel disease. This article will review the recent research on cerebral small vessel disease based on 7 T-MRI and discuss potential issues and future research directions,offering references for researchers in the field.

cerebral small vessel diseasemagnetic resonance imagingultra-high fieldtime-of-flight magnetic resonance angiographyphase-contrast magnetic resonance angiographysusceptibility-weighted imaging

黄沛钰、刘晨、甄志铭、张睿婷

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浙江大学医学院附属第二医院放射科,杭州 310009

陆军军医大学第一附属医院放射科7 T磁共振转化医学研究中心,重庆 400038

脑小血管病 磁共振成像 超高场强 时间飞跃法磁共振血管成像 相位对比磁共振血管成像 磁敏感加权成像

国家自然科学基金项目国家自然科学基金项目

8237190782101987

2024

10.12015/issn.1674-8034.2024.09.026

磁共振成像
中国医院协会 首都医科大学附属北京天坛医院

磁共振成像

CSTPCD北大核心
影响因子：1.38
ISSN：1674-8034
年,卷(期)：2024.15(9)