心脏毒性是免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)治疗恶性肿瘤的潜在并发症.虽然ICIs相关心脏毒性发生率较低,但可威胁患者生命.心脏磁共振(cardiac magnetic resonance,CMR)有更好的软组织分辨率及多功能、多参数成像的优点,其中电影序列、延迟强化序列(late gadolinium enhancement,LGE)、T1 mapping、T2 mapping、特征追踪技术(feature tracking,FT)等在ICIs相关心脏毒性全方位评估以及早期诊断、风险分层发挥着关键作用,本文通过总结这些技术对ICIs相关心脏毒性进行的定量、定性分析,为临床早期诊断ICIs相关心脏毒性提供新的方法与思路,以确保患者在接受治疗过程中的安全性,从而提高患者的生存质量,并有望为将来的研究提供参考方向.
Advances in magnetic resonance imaging research on cardiotoxicity of immune checkpoint inhibitors
Cardiotoxicity is a potential complication of immune checkpoint inhibitors (ICIs) in the treatment of malignant tumors. Although the incidence of ICIs-related cardiotoxicity is low,it can threaten the lives of patients. Cardiac magnetic resonance imaging (CMR) imaging has the advantages of better soft tissue resolution and multi-functional,multi-parameter imaging. Techniques such as cine sequences,late gadolinium enhancement (LGE),T1 mapping,T2 mapping,and feature tracking (FT) play a crucial role in the comprehensive assessment and early diagnosis of ICIs-related cardiotoxicity. This article summarizes the quantitative and qualitative analysis of ICIs-related cardiotoxicity through these techniques,and provides new methods and ideas for early clinical diagnosis of ICIs-related cardiotoxicity,so as to ensure the safety of patients during treatment,thereby improving the quality of life of patients,and is expected to provide reference direction for future research.
cardiac magnetic resonanceimmune checkpoint inhibitorscardiotoxicitymagnetic resonance imagingT1 mappingfeature tracking
万方数据
维普
