Advances in magnetic resonance imaging research on cardiotoxicity of immune checkpoint inhibitors
骆书颖 1余洪 1李邦国1
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作者信息
1. 遵义医科大学附属医院放射科贵州省医学影像中心,遵义 563003
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摘要
心脏毒性是免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)治疗恶性肿瘤的潜在并发症.虽然ICIs相关心脏毒性发生率较低,但可威胁患者生命.心脏磁共振(cardiac magnetic resonance,CMR)有更好的软组织分辨率及多功能、多参数成像的优点,其中电影序列、延迟强化序列(late gadolinium enhancement,LGE)、T1 mapping、T2 mapping、特征追踪技术(feature tracking,FT)等在ICIs相关心脏毒性全方位评估以及早期诊断、风险分层发挥着关键作用,本文通过总结这些技术对ICIs相关心脏毒性进行的定量、定性分析,为临床早期诊断ICIs相关心脏毒性提供新的方法与思路,以确保患者在接受治疗过程中的安全性,从而提高患者的生存质量,并有望为将来的研究提供参考方向.
Abstract
Cardiotoxicity is a potential complication of immune checkpoint inhibitors (ICIs) in the treatment of malignant tumors. Although the incidence of ICIs-related cardiotoxicity is low,it can threaten the lives of patients. Cardiac magnetic resonance imaging (CMR) imaging has the advantages of better soft tissue resolution and multi-functional,multi-parameter imaging. Techniques such as cine sequences,late gadolinium enhancement (LGE),T1 mapping,T2 mapping,and feature tracking (FT) play a crucial role in the comprehensive assessment and early diagnosis of ICIs-related cardiotoxicity. This article summarizes the quantitative and qualitative analysis of ICIs-related cardiotoxicity through these techniques,and provides new methods and ideas for early clinical diagnosis of ICIs-related cardiotoxicity,so as to ensure the safety of patients during treatment,thereby improving the quality of life of patients,and is expected to provide reference direction for future research.
关键词
心脏磁共振/免疫检查点抑制剂/心脏毒性/磁共振成像/T1/mapping/特征追踪技术
Key words
cardiac magnetic resonance/immune checkpoint inhibitors/cardiotoxicity/magnetic resonance imaging/T1 mapping/feature tracking
维普
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