Application of MOLLI T1 mapping quantitative technology in the assessment of pediatric brain development
Objective:To explore the value of the modified Look-Locker inversion recovery(MOLLI)T1 mapping quantitative technique in evaluating the development of brain in children quantitatively.Materials and Methods:Fifty-three children with normal head magnetic resonance imaging results were included,and optimized MOLLI and magnetization prepared 2 rapid acquisition gradient echoes(MP2RAGE)sequences were used to perform T1 mapping quantitative analysis on 36 brain regions of each subject.We evaluate the consistency of T1 values in each brain region obtained from two sequences,compared the differences in T1 values in each brain region of the two sequences,and analyze the correlation between T1 values in each brain region of the two sequences and age.Results:The intraclass correlation co-efficient(ICC)for the MOLLI sequence and MP2RAGE sequence in all brain regions were greater than 0.8(P＜0.001),except for the bilateral dorsal pontine and cerebral peduncle.The differences in T1 values between the two sequences in each brain region were statistically significant(P＜0.05,FDR-corrected),the T1 values in each brain region of the MOLLI group were higher than those in the MP2RAGE group.The T1 values of each brain region in both sequences were negatively correlated with age(P＜0.001).Conclusions:The optimized MOLLI sequence can be used for the quantitative evaluation of brain development in children,showing good consistency with MP2RAGE sequence,and accurately quantifying T1 values of brain regions,providing a new sequence selection for the study of the nervous system of fetuses and children.
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