Feasibility of compressed sensing cine imaging for analysis of left ventricular strain in cardiac MRI
Objective:Explore the feasibility of using single-shot compressed sensing real-time cine(RT-CS)and two-shots compressed sensing cine(2 shots-CS)cardiac magnetic resonance(CMR)sequences to assess left ventricular(LV)strain.Materials and Methods:Sixty-four patients undergoing CMR were prospectively enrolled.Each patient underwent conventional segmented cine(Seg),2 shots-CS,and RT-CS.The acquisition time for each sequence was recorded.Using Seg as the"gold standard",the image quality of the three cine sequences was evaluated,including subjective assessment,artifact evaluation,and edge sharpness.LV volumetric and functional parameters,as well as global and regional strain parameters(basal,mid,apical),were measured.Bland-Altman plots and intra-class correlation coefficients(ICC)were used to compare the consistency of LV volumetric and functional parameters and strain measurements obtained from the three sequences.Results:Acquisition time for Seg,2 shots-CS,and RT-CS was(271.72±87.74)s,(62.19±33.09)s,and(29.39±20.60)s,respectively,with statistically significant differences(P＜0.001).Subjective image quality ratings showed no significant difference between Seg and 2 shots-CS(P=0.122),but RT-CS had lower ratings than Seg(P=0.001).Artifacts were less pronounced in RT-CS than in both Seg(P=0.038)and 2 shots-CS(P=0.022),while there was no significant difference between Seg and 2 shots-CS(P=0.825).Edge sharpness in 2 shots-CS was similar to Seg(P=0.068),but RT-CS showed significantly lower sharpness than Seg(P＜0.001).In quantitative left ventricular function analysis,end-diastolic volume(EDV)and stroke volume(SV)were lower in 2 shots-CS compared to Seg(P＜0.001),while end-systolic volume(ESV),ejection fraction(EF),and left ventricular mass(LVM)did not significantly differ between 2 shots-CS and Seg(P＞0.05).All functional volumetric parameters in RT-CS were lower than in Seg,with statistically significant differences(P＜0.05).Both CS sequences showed excellent agreement with Seg for volumetric and functional parameters(ICC＞0.910).For strain analysis,both 2 shots-CS and RT-CS showed lower radial strain(RS),circumferential strain(CS),and longitudinal strain(LS)values compared to Seg,with RT-CS values being the lowest,and all differences were statistically significant(P＜0.05).Except for apical RS(ICC=0.559,0.529),strain values in 2 shots-CS and RT-CS showed good to excellent agreement with Seg(ICC=0.776-0.950 for 2 shots-CS;0.716-0.941 for RT-CS).Global strain showed higher consistency than regional strain in both CS sequences,with 2 shots-CS demonstrating higher consistency than RT-CS.Conclusions:Both CS cine sequences significantly reduced scan time while maintaining acceptable image quality.In particular,2 shots-CS showed good agreement with Seg in strain measurements,with global strain showing better consistency than regional strain.However,strain values from CS cine sequences were lower than those from Seg.To avoid measurement discrepancies due to sequence variation,it is recommended to use the same cine sequence consistently in follow-up of chronic conditions.
magnetic resonance imagingcardiac magnetic resonancecinecompressed sensingstrainfeature tracking
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