神经退行性疾病认知灵活性改变的行为学及影像学研究进展
Advances in behavior and imaging studies of cognitive flexibility changes in neurodegenerative disease
曹馨予 1于瀛 2胡博 2颜林枫 2崔光彬2
作者信息
- 1. 延安大学医学院,延安 716000;空军军医大学唐都医院放射科暨陕西省功能与分子影像重点实验室,西安 710038
- 2. 空军军医大学唐都医院放射科暨陕西省功能与分子影像重点实验室,西安 710038
- 折叠
摘要
认知灵活性是指个体能够迅速适应不断变化的环境,并在这个过程中迅速切换思维模式并产生适应行为反应的能力.在阿尔茨海默病、帕金森病和肌萎缩侧索硬化等神经退行性疾病中可以观察到患者灵活转变自身心理过程和行为以适应环境变化的能力显著下降(即认知灵活性受损).本文旨在回顾并总结以往关于神经退行性疾病认知灵活性的行为学评估方法和影像学研究进展,为神经退行性疾病引起的认知灵活性减退的诊断和治疗提供理论基础.
Abstract
Cognitive flexibility refers to the individual to be able to quickly adapt to changing circumstances,and in the process to switch quickly thinking mode and the ability of adaptation in response.In neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease and amyotrophic lateral sclerosis can be observed in the patients with flexibly shift their own mental processes and behavior to adapt the environment change ability dropped significantly(i.e,impaired cognitive flexibility).This article aims to review and summarize the previous research progress on behavioral assessment methods and imaging studies of cognitive flexibility in neurodegenerative diseases,so as to provide a theoretical basis for the diagnosis and treatment of cognitive flexibility decline caused by neurodegenerative diseases.
关键词
认知灵活性/神经退行性疾病/磁共振成像/阿尔茨海默病/帕金森病/威斯康星卡片分类测试Key words
cognitive flexibility/neurodegenerative diseases/magnetic resonance imaging/Alzheimer's disease/Parkinson's disease/Wisconsin Card Sorting Test引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据