核磁共振(nuclear magnetic resonance,NMR)光谱学中的核奥氏效应(nuclear overhauser effect,NOE)是能够提供分子内部和分子间距离与构象信息的关键现象.通过分析NOE效应,能够深入解析分子结构,尤其是复杂生物分子和药物分子的三维构象,这对于现代医学的发展具有重要意义.随着精准医学的迅猛发展,NOE效应在药物设计、疾病诊断和个性化治疗中的应用潜力日益凸显.本文综述了 NOE效应在精准医学中的多方面应用,重点分析了其在药物分子与靶标蛋白结合方式的解析、病理状态下生物分子构象变化的检测,以及个性化治疗中生物标志物的识别等方面的贡献.同时,结合具体的案例研究和实验数据,进一步阐述了 NOE效应在从基础研究到临床应用中的重要作用.本综述展示了 NOE效应在现代医学中所具有的广泛应用前景,并指出其未来在精准医疗中可能的突破点,为进一步研究和应用提供了新的方向和思路.
Potential of the nuclear overhauser effect in precision medicine:From basic research to clinical applications
The nuclear overhauser effect(NOE)in nuclear magnetic resonance(NMR)spectroscopy is a critical phenomenon that provides essential information on intra-and intermolecular distances and conformations.By analyzing the NOE effect,researchers can gain deeper insights into molecular structures,particularly the three-dimensional conformations of complex biomolecules and pharmaceutical compounds,which are of great significance for the advancement of modern medicine.With the rapid growth of precision medicine,the application potential of the NOE effect in drug design,disease diagnosis,and personalized therapy has become increasingly prominent.This review focuses on the various applications of the NOE effect in precision medicine,with an emphasis on its contributions to elucidating drug-target interactions,detecting conformational changes in biomolecules under pathological conditions,and identifying biomarkers for personalized treatment.Specific case studies and experimental data are incorporated to further explain the role of the NOE effect in bridging basic research and clinical applications.Through this review,the broad application prospects of the NOE effect in modem medicine are demonstrated,and potential breakthroughs in precision medicine are highlighted,offering new directions and insights for future research and applications.
glioblastomaAlzheimer's diseasenuclear magnetic resonancenuclear overhauser effectmagnetic resonance imagingprecision medicine
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