Chinese expert consensus on MRI evaluation of endocrine system immune-related adverse events induced by immune checkpoint inhibitors in malignant tumors
Chinese expert consensus on MRI evaluation of endocrine system immune-related adverse events induced by immune checkpoint inhibitors in malignant tumors
Immune checkpoint inhibitors(ICIs)demonstrate potent anti-tumor effects by reactivating effector T cells to eliminate cancer cells.However,this modulation of the immune response can also lead to activation of immune cells,triggering autoimmune damage,known as immune-related adverse events(irAEs).Among these adverse reactions,endocrine system disorders are particularly common,primarily affecting endocrine glands such as the thyroid,pituitary,and adrenal glands,leading to endocrine dysfunction.MRI plays a crucial role in the early diagnosis and assessment of endocrine system irAEs.However,there is currently no standardized consensus in China regarding MRI examination and diagnosis of endocrine system irAEs caused by ICIs.For this purpose,the Molecular Imaging Group,Magnetic Resonance Group,and Neurology Group of the Radiology Branch of the Chinese Medical Association,together with the Editorial Board of Chinese Journal of Magnetic Resonance Imaging,jointly established an expert committee.Drawing extensively from the literature,combined with expert experience and internal discussions,the committee ultimately developed this consensus.The aim of this consensus is to provide guidance and support to radiologists and clinicians in diagnosing endocrine system irAEs using MRI.
关键词
磁共振成像/免疫检查点抑制剂/内分泌系统免疫相关不良反应/临床应用/专家共识
Key words
magnetic resonance imaging/immune checkpoint inhibitors/endocrine system immune-related adverse events/clinical application/expert consensus
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