Analysis of topological properties of brain functional networks in adolescents with non-suicidal self-injury based on graph theory
Objective:To construct and analyze the changes in topological properties of brain functional networks in adolescent non-suicidal self-injury(NSSI)patients based on graph theory.Materials and Methods:Thirty-five adolescent NSSI patients(NSSI group)and 24 healthy controls(control group)were enrolled in the study.Their resting-state functional magnetic resonance imaging data were collected,and the brain functional network was constructed and binarized for graph theory analysis.The network characteristic parameters of the NSSI group and the control group were compared by independent sample t-test,and their correlation with the number of self-injury and addiction characteristics was analyzed.Results:Compared with the Control group,the small-world attribute of the NSSI group decreased,and the characteristic path length increased,and the difference was statistically significant(P<0.05).In the NSSI group,the betweenness centrality of the right olfactory cortex and right amygdala increased,while that of the left fusiform gyrus and left superior temporal gyrus decreased(P all<0.05);The node centrality of the right amygdala increased,while that of the left superior temporal gyrus,right superior temporal gyrus,and left middle temporal gyrus decreased(P all<0.05);The node clustering coefficient of the left precuneus increased,while that of the orbital inferior frontal gyrus,left supplementary motor area,left insula,right superior occipital gyrus,and right fusiform gyrus decreased(P all<0.05);The node efficiency of the left middle frontal gyrus,right posterior cingulate gyrus,right amygdala,and right precuneus increased,while that of the superior temporal gyrus decreased(P all<0.05);The node local efficiency of the precuneus increased,while that of the right fusiform gyrus and right temporal pole decreased(P all<0.05).The node clustering coefficient of the left supplementary motor area in the NSSI group was positively correlated with the number of self-injury in the past month(r=0.426,P<0.05);The node clustering coefficient of the right superior occipital gyrus,the node local efficiency of the right fusiform gyrus,and the node efficiency of the left middle frontal gyrus were negatively correlated with the score of the self-injury addiction characteristic scale(r=-0.335,-0.415,-0.404,P all<0.05).Conclusions:The reduction of the global integration ability of NSSI adolescent brain network and the reduction of information transmission efficiency in the prefrontal cortex are closely related to the characteristics of self-injury addiction,which provides a new perspective for elucidating the brain function mechanism of self-injury addiction psychological disorder in NSSI patients,and is helpful for adolescent mental health intervention and treatment.
万方数据
维普
