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孤独症谱系障碍的神经影像学特征与遗传机制:多模态数据整合的现状与展望

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孤独症谱系障碍(autism spectrum disorder,ASD)是一种复杂的神经发育障碍,其病理机制涉及神经影像学异常与遗传因素的交互作用.本文综述了ASD的神经影像学特征及遗传变异对脑结构与功能的特异性影响,探讨了神经影像与遗传学数据整合在解析ASD病理机制中的重要作用,同时指出了现有研究局限并提出未来展望,以期为ASD的精准诊断与个性化干预提供新的方向.
Neuroimaging characteristics and genetic mechanisms of autism spectrum disorder:The current status and prospects of multimodal data integration
Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder,the pathological mechanism of which involves the interaction between neuroimaging abnormalities and genetic factors.This paper reviews the neuroimaging characteristics of ASD and the specific effects of genetic variations on brain structure and function,exploring the important role of integrating neuroimaging and genetic data in deciphering the pathological mechanisms of ASD.It also points out the limitations of existing research and proposes future prospects,aiming to provide new directions for the precise diagnosis and personalized intervention of ASD.

autism spectrum disordersneuroimagingmagnetic resonance imagingmultimodal imaginggenetics

罗丹、赵纯风、刘衡

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遵义医科大学附属医院放射科,贵州省高等学校智能医学影像工程研究中心,贵州省医学影像中心,遵义 563000

孤独症谱系障碍 神经影像学 磁共振成像 多模态影像 遗传学

2024

磁共振成像
中国医院协会 首都医科大学附属北京天坛医院

磁共振成像

CSTPCD北大核心
影响因子:1.38
ISSN:1674-8034
年,卷(期):2024.15(12)