随着人类寿命的延长,以衰老为主要危险因素的神经退行性疾病的患病率也在增加,这导致了严重的医学和社会经济问题.扩散张量成像(diffusion tensor imaging,DTI)是一种能无创探测脑微观结构改变的磁共振成像技术,广泛应用于神经退行性疾病的临床和研究.但是由于部分容积效应等原因,可能影响了DTI测量的准确性.自由水扩散张量成像(free water DTI,FW-DTI)不仅在很大程度上弥补了上述缺陷,还可以增强标准DTI指标对神经退行性疾病的敏感性.本文将针对目前FW-DTI技术在神经退行性疾病中的研究进展予以综述,以期为今后的研究提供新的思路.
Research progress of free water diffusion tensor imaging in neurodegenerative diseases
As people live longer,the prevalence of neurodegenerative diseases with aging as a major risk factor is also increasing,which leads to serious medical and socioeconomic problems.Diffusion tensor imaging(DTI)is a magnetic resonance imaging technique that can noninvasively detect brain microstructure changes,and is widely used in clinical and research of neurodegenerative diseases.However,due to the partial volume effect and other reasons,the accuracy of DTI measurement may be affected.Free water diffusion tensor imaging(FW-DTI)not only makes up for the above deficiencies to a large extent,but also enhances the sensitivity of standard DTI indicators to neurodegenerative diseases.This article will review the current research progress of FW-DTI technology in neurodegenerative diseases,in order to provide new ideas for future research.
neurodegenerative diseasesAlzheimer's diseaseParkinson's diseasefree water diffusion tensor imagingmagnetic resonance imaging
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