人类小脑虽然体积很小,但在运动控制、平衡维持以及认知功能等方面,却发挥着至关重要的作用.多种疾病,尤其是神经退行性疾病(neurodegenerative diseases,NDs),在发展过程中会累及小脑,严重影响患者日常生活.因此,对NDs患者小脑的研究,有助于我们理解其病理机制.目前,小脑高场磁共振成像(high field magnetic resonance imaging,HF-MRI)在NDs中的应用,为小脑结构及功能的改变提供了大量影像学证据.更先进的小脑超高场磁共振成像(ultra high field magnetic resonance imaging,UHF-MRI)允许我们进一步研究小脑的细微结构及功能特点,具有广阔前景,但尚未广泛应用于NDs研究中.本文综述了小脑HF-MRI及UHF-MRI的研究进展及在NDs中的应用,分析了小脑UHF-MRI成像优势及挑战.未来有望在小脑UHF-MRI赋能下,从小脑角度出发,寻找早期精确诊断NDs的神经影像生物标记物.
Progress in cerebellar high-field and ultra-high-field magnetic resonance imaging and their applications in neurodegenerative diseases
Although the cerebellum of humans is quite small in volume,it plays a crucial role in motor control,balance maintenance,and cognitive functions.A variety of diseases,especially neurodegenerative diseases,involve the cerebellum during their progression,severely affecting the daily lives of patients.Therefore,studying the cerebellum in patients with neurodegenerative diseases(NDs)helps us understand their pathological mechanisms.Currently,the application of cerebellar high field magnetic resonance imaging(HF-MRI)in NDs has provided a wealth of imaging evidence for changes in cerebellar structure and function.Advanced ultra-high field magnetic resonance imaging(UHF-MRI)of the cerebellum allows us to further investigate the subtle structures and functional characteristics of the cerebellum,which holds broad prospects,but has not yet been widely applied in the study of NDs.This paper reviews the research progress of cerebellar HF-MRI and UHF-MRI,as well as their applications in NDs,and analyzes the advantages and challenges of cerebellar UHF-MRI.In the future,with the empowerment of cerebellar UHF-MRI,there is hope to identify neuroimaging biomarkers for the early and precise diagnosis of NDs from the cerebellar perspective.
万方数据
维普
