Mechanism of Bodanpi Extract in Inhibiting TGF-β1 Signaling Pathway for the Treatment of Asthmatic Mice
Objective To investigate the effect of Bodanpi extract on airway inflammation and remodeling in an asthma mouse model through the regulation of transforming growth factor-β1(TGF-β1)signaling pathway protein expression.Methods An asthma model was established in BALB/c mice using house dust mite(HDM)extract.The mice were divided into normal,model,Bodanpi extract-treated,and dexamethasone-treated groups.Evaluations included measurements of airway hyperresponsiveness(AHR),serum IgE levels,lung tissue pathology,inflammatory cytokines in bronchoalveolar lavage fluid(BALF),and protein expression of TGF-β,small mother against decapentaplegic 2(SMAD2),and α-smooth muscle actin(α-SMA)in lung tissue.Results Bodanpi extract demonstrated potential in reducing AHR and serum IgE levels in the asthma model.Additionally,the extract might alleviate lung tissue fibrosis and inflammation,possibly through the inhibition of inflammatory cytokines in BALF and key proteins(TGF-β,SMAD2,and α-SMA)in the TGF-β1 signaling pathway in lung tissue.Conclusion Bodanpi extract shows promise as a potential treatment for asthma,with its mechanism likely related to the inhibition of the TGF-β1 signaling pathway;however,further research is needed to validate this mechanism.
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