Objective To investigate the causal relationship between coffee intake and the incidence of immunoglobulin A nephropathy(IgAN)using the Mendelian randomization(MR)method.Methods Single nucleotide polymorphisms(SNPs)associated with coffee consumption were extracted from genome-wide association studies(GWAS)as instrumental variables.Two-sample MR analyses were performed using inverse variance weighting(IVW),weighted median method,weighted analysis,MR-Egger method,and simple analysis to evaluate the causal relationship between coffee consumption and IgAN.Results Thirty relevant SNPs were identified.The IVW results showed no causal relationship between coffee consumption and the risk of IgAN(OR=0.887,95％CI:0.591-1.329).The weighted median method indicated no causal relationship(OR=1.051,95％CI:0.625-1.760).Weighted analysis similarly showed no causal relationship(OR=1.063,95％CI:0.612-1.844).MR-Egger analysis also revealed no causal relationship(OR=1.298,95％CI:0.531-3.172).And simple analysis results confirmed no causal relationship(OR=0.815,95％CI:0.316-2.098).Sensitivity analysis indicated no bias in the results,and heterogeneity tests showed no heterogeneity among SNPs.Conclusion There is no causal relationship between coffee consumption and IgAN.
关键词
咖啡摄入/免疫球蛋白A肾病/孟德尔随机化/全基因组关联分析
Key words
Coffee intake/Immunoglobulin A nephropathy/Mendelian randomization/Genome-wide association studies
维普
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