Analysis of the Correlation Between Serum 25(OH)D3 and 8-OHdG Levels and Mild Cognitive Impairment in Patients with Obstructive Sleep Apnea Hypopnea Syndrome
Objective To investigate the correlation between serum 25-hydroxyvitamin D3[25(OH)D3]and 8-hydroxy-2'-deoxyguanosine(8-OHdG)levels and mild cognitive impairment(MCI)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 159 patients with OSAHS in Xi'an No.9 Hospital from June 2022 to June 2024 were include in the OSAHS group.They were further divided into the MCI group(n=107)and the normal cognition group(n=52)according to the diagnostic criteria of MCI.And 159 healthy subjects were selected as the healthy control group.Spearman analysis was utilized to analyze the correlation between serum 25(OH)D3 and 8-OHdG levels and Montreal Cognitive Assessment(MoCA)score in OSAHS patients with MCI.Logistic regression analysis was used to analyze the factors influencing the occurrence of MCI in OSAHS patients.And the predictive value of serum 25(OH)D3 and 8-OHdG for MCI in patients with OSAHS was analyzed by receiver operating characteristic(ROC)curve.Results Compared with the healthy control group,the OSAHS group exhibited decreased serum 25(OH)D3 level and increased serum 8-OHdG level(P＜0.05).Compared with the normal cognition group,the MCI group showed a decrease in serum 25(OH)D3 level and an increase in serum 8-OHdG level(P＜0.05).Serum 25(OH)D3 level was positively correlated with MoCA score,while serum 8-OHdG was negatively correlated with MoCA score(r=0.374,-0.301,P＜0.05).Age,smoking,oxygen saturation＜90％time as a percentage of total monitoring time,and serum 8-OHdG were risk factors for MCI in OSAHS patients,while MoCA score,total sleep time,and serum 25(OH)D3 were protective factors for MCI in OSAHS patients(P＜0.05).The area under the curve(AUC)of serum 25(OH)D3 in predicting MCI in OSAHS patients was 0.829(95％CI:0.762-0.896),with a sensitivity of 78.50％and a specificity of 80.77％.The AUC of serum 8-OHdG in predicting MCI in OSAHS patients was 0.817(95％CI:0.744-0.889),with a sensitivity of 83.18％and a specificity of 82.69％.The AUC of the combined detection of serum 25(OH)D3 and 8-OHdG in predicting MCI in OSAHS patients was 0.908(95％CI:0.857-0.959),with a sensitivity of 92.52％and a specificity of 78.85％.The combination of serum 25(OH)D3 and 8-OHdG had a better predictive value for MCI in OSAHS patients(P＜0.05).Conclusion Decreased serum 25(OH)D3 and elevated serum 8-OHdG increase the risk of MCI in OSAHS patients.Serum 25(OH)D3 and 8-OHdG have certain predictive value for MCI in OSAHS patients.
万方数据
维普
