Correlation Between Serum High-Sensitivity C-Reactive Protein and Procalcitonin Levels and Maternal and Infant Outcomes of Premature Rupture of Membranes Infected by Group B Streptococcus
Objective To observe the correlation between serum high-sensitivity C-reactive protein(hs-CRP)and procalcitonin(PCT)levels and maternal and infant clinical outcomes in patients with preterm premature rupture of membranes(PROM)infected by group b streptococcus(GBS).Methods A total of 105 patients with PROM in Suining Central Hospital from may 2021 to may 2024 were selected as the study objects.They were divided into a GBS infection group(n=64)and a non-GBS infection group(n=41)according to the presence or absence of GBS.The pregnant women in the GBS infection group were further classified into an intrauterine infection group(n=39)and a non-intrauterine infection group(n=25)according to the presence or absence of intrauterine infection.The newborns were divided into an infectious pneumonia group(n=38)and a non-infectious pneumonia group(n=26)according to the presence or absence of pulmonary infection,and were divided into a sepsis group(n=15)and a non-sepsis group(n=49)according to the presence or absence of progression to sepsis.Levels of serum hs-CRP and PCT were detected among PROM patients,and their correlation with perinatal maternal-infant GBS infection was analyzed.Results The levels of serum hs-CRP and PCT in the GBS infection group were higher than those in the non-GBS infection group(P＜0.05).The serum hs-CRP and PCT levels in the intrauterine infection group were higher than those in the non-intrauterine infection group(P＜0.05),and the above levels in the neonatal infectious pneumonia group were higher than those in the non-infectious pneumonia group(P＜0.05),and were higher in the sepsis group than those in the non-sepsis group(P＜0.05).Receiver operating characteristic(ROC)curve indicated that the areas under the roc curve(AUCs)of hs-CRP and PCT levels were 0.794 and 0.750 in evaluating intrauterine infection of PROM,0.824 and 0.828 in assessing neonatal infectious pneumonia,and 0.785 and 0.835 in evaluating sepsis,respectively.Conclusion PROM with GBS infection may induce maternal postpartum intrauterine infection,and neonatal pneumonia and sepsis,and is correlated with serum hs-CRP and PCT levels.
Premature rupture of membranesGroup B StreptococcusHigh-sensitivity C-reactive proteinProcalcitonin
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