Retinopathy of Prematurity:A Re-exploration of Oxygen-Related Risk Factors Analysis
Objective To investigate the risk factors of retinopathy of prematurity(ROP)and analyze the correlation between the concentration of inhaled oxygen(COI)and the incidence of ROP based on the results of early fundus screening and follow-up data.Methods A retrospective examination was performed on the clinical documentation and follow-up results of preterm infants admitted to the Neonatal Intensive Care Unit(NICU)of Xiangyang Central Hospital from January 2020 to December 2022,specifically focusing on those who met the criteria for ROP screening.A total of 74 cases were included and divided into a control group(without ROP,n=58)and an experimental group(with ROP,n=16)based on the occurrence or absence of ROP.Results The incidence of ROP was 21.6％among the 74 preterm infants.In the ROP group,68.8％were male,with a mean gestational age of(212.3±13.5)d,a mean birth weight of(1.5±0.3)kg,a median duration of oxygen therapy of 13.5(4.2,28.0)d,and a median oxygen concentration of 30％(26.3％,35.0％).In the control group,60.3％were male,with a mean gestational age of(225.4±21.9)d,a mean birth weight of(1.7±0.4)kg,a median duration of oxygen therapy of 7.5(0.0,16.3)d,and a median oxygen concentration of 24.0％(21.0％,25.5％).Multivariate Logistic regression analysis revealed that gestational age(OR=0.931,95％CI 0.871-0.976,P=0.020),oxygen concentration(OR=1.142,95％CI:1.021-1.228,P=0.032),and duration of oxygen therapy(OR=1.046,95％CI:1.013-1.092,P=0.041)were independently associated with the occurrence of ROP.Smooth curve fitting analysis demonstrated a dose-dependent relationship between oxygen concentration and ROP incidence.Specifically,when oxygen concentration was below 30％,the risk of ROP increased with the increase of oxygen concentration,while above 30％,the risk plateaued and did not significantly increase further.Conclusion Gestational age,COI and duration of oxygen therapy are independent risk factors for ROP.For children at risk of ROP,COI should be carefully increased to avoid increasing the risk of ROP.
万方数据
维普
