Changes of VEGF,CRP,IL-6,and PCT in Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Fibrosis
Objective To explore the chest computed tomography(CT)findings and changes in serum levels of vascular endothelial growth factor(VEGF),C-reactive protein(CRP),interleukin-6(IL-6),and procalcitonin(PCT)in patients with chronic obstructive pulmonary disease(COPD)complicated by pulmonary fibrosis(PF).Methods A total of 124 patients with COPD complicated with PF who received treatment at the First Affiliated Hospital of Henan University of Chinese Medicine from January 2020 to February 2024 were selected as the experimental group,and 124 patients with COPD alone admitted during the same period were selected as the control group.The chest CT findings,clinical data,and serum levels of VEGF,CRP,IL-6,and PCT were compared between the two groups.Multivariate Logistic regression analysis was utilized to analyze the risk factors for COPD complicated with PF.The diagnostic value of combined detection of serum VEGF,CRP,IL-6,and PCT levels for COPD patients complicated with PF was analyzed using receiver operating characteristic(ROC)curves.Results The independent risk factors for COPD complicated with PF included advanced age,long course of COPD,smoking history,acute exacerbation of COPD,pulmonary function grade of 3-4,smoke/dust working environment,high frequency of acute exacerbation,and high levels of serum VEGF,CRP,IL-6,and PCT(P＜0.05).The areas under the curve(AUCs)of serum VEGF,CRP,IL-6 and PCT levels and their combined detection for the diagnosis of COPD complicated with PF were 0.650,0.689,0.667,0.702,and 0.913,respectively.The sensitivities were 63.71％,64.52％,62.10％,71.77％,and 88.71％,and the specificities were 62.90％,69.35％,71.77％,64.52％,and 81.45％,respectively.The AUC of their combined detection was higher than that of single detection(P＜0.05).Compared with the control group,the experimental group showed higher proportion of patients with grid like shadows,ground glass like shadows,and punctate and honeycomb like shadows(P＜0.05).Conclusion Chest CT examination has certain application value in the diagnosis of COPD combined with PF.Independent risk factors for COPD combined with PF include long course of COPD,advanced age,acute exacerbation of COPD,smoking history,smoke/dust working environment,pulmonary function grade of 3-4,and high frequency of acute exacerbation.Serum VEGF,CRP,IL-6,and PCT levels have high application value in the diagnosis of COPD combined with PF,with the highest diagnostic value achieved by their combined detection.
万方数据
维普
