Efficacy of Febuxostat Combined with Potassium Citrate Granules in Patients with Gout,Hyperuricemia and Renal Calculus
Objective To investigate the efficacy of febuxostat combined with potassium citrate granules in the treatment of patients with gout,hyperuricemia and kidney stones.Method A total of 122 patients with gout,hyperuricemia and kidney stones admitted to Guangyuan Central Hospital from September 2020 to January 2024 were included.They were randomly divided into three groups according to a random number table method.Group A(n=42)was treated with combination therapy of febuxostat(80 mg/d)and potassium citrate granules,Group B(n=42)was treated with combination therapy of febuxostat(40 mg/d)and potassium citrate granules,while Group C(n=30)was treated with potassium citrate granules alone.The clinical efficacy,degree of pain relief,micro-inflammatory status,cytokines,renal function indicators,adverse reactions,and prognosis were compared between the three groups.Results The total effective rate in Group A was higher than that in Group B and Group C(P＜0.05).The Visual Analog Scale(VAS)scores in Group A were lower than those in Group B and Group C after 3 months of treatment(P＜0.05).After treatment,the levels of interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),serum high-sensitivity C-reactive protein(hs-CRP),endothelin-1(ET-1),soluble intercellular adhesion molecule-1(sICAM-1),serum blood urea nitrogen(BUN),serum creatinine(Scr),and serum uric acid in Group A were all lower than those in Group B and Group C(P＜0.05).There was no significant difference in the incidence of adverse reactions and recurrence rate of kidney stones among the three groups(P＞0.05).During follow-up,the frequency of gout attacks in Group A was lower than that in Group B and Group C(P＜0.05).Conclusion The combination of febuxostat and potassium citrate granules can help improve the efficacy in the treatment of patients with gout,hyperuricemia and kidney stones by,reducing inflammation levels,and improving kidney function.And high-dose febuxostat has better efficacy and prognosis,as well as certain safety.
GoutHyperuricemiaRenal calculusFebuxostatPotassium citrateRenal function
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维普
