Correlation Analysis Between Serum NGF and VILIP-1 Levels and Cognitive Function in Children with Epilepsy and Attention Deficit Hyperactivity Disorder
Objective To analyze the serum levels of nerve growth factor(NGF)and visinin-like protein-1(VILIP-1)in children with epilepsy and attention deficit hyperactivity disorder(ADHD)and their correlation with cognitive function.Methods A total of 95 children with epilepsy and ADHD admitted to Hebei Children's Hospital from December 2020 to November 2023 were included in the epilepsy+ADHD group,95 children with simple epilepsy were recruited as the epilepsy group,and 95 healthy children undergoing medical checkups in Hebei Center for Women and Children's Health were taken as the control group.Enzyme-linked immunosorbent assay(ELISA)was utilized to detect serum NGF and VILIP-1 levels.Combined Rave's Test(CRT),P300-Event Related Potential,and Wechsler Intelligence Scale for Children Fourth Edition(WISC-Ⅳ)were used for cognitive assessment of children in the epilepsy+ADHD group and the epilepsy group.Spearman correlation analysis was employed to analyze the correlation between serum NGF and VILIP-1 levels and cognitive function in children with epilepsy and ADHD.Results The serum NGF and VILIP-1 levels in the epilepsy+ADHD group and the epilepsy group were higher than those in the control group(P＜0.05),and the above two levels in the epilepsy+ADHD group were higher than those in the epilepsy group(P＜0.05).The similarity comparison,series relationship,comparative reasoning,abstract reasoning,perceptual discrimination,and intelligence quotient(IQ)of children in the epilepsy+ADHD group were lower than those in the epilepsy group(P＜0.05).Compared with the epilepsy group,the epilepsy+ADHD group showed an increase in P300 latency but a decrease in P300 amplitude(P＜0.05).The speech comprehension,perceptual reasoning,working memory,processing speed,and full-scale intelligence quotient(FSIQ)of children in the epilepsy+ADHD group were lower than those in the epilepsy group(P＜0.05).The levels of serum NGF and VILIP-1 were negatively correlated with similarity comparison,series relationship,comparative reasoning,abstract reasoning,perceptual discrimination,IQ,P300 amplitude,speech comprehension,perceptual reasoning,working memory,processing speed,and FSIQ in children with ADHD and epilepsy(P＜0.05),and positively correlated with P300 latency(P＜0.05).Conclusion The serum levels of NGF and VILIP-1 are elevated in children with ADHD and epilepsy,both of which are related to their cognitive function.
EpilepsyAttention deficit hyperactivity disorderNerve growth factorVisinin-like protein-1Cognitive function
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