首页|自拟中药方对急性结石性胆囊炎术后中医证候和免疫应激的影响研究

自拟中药方对急性结石性胆囊炎术后中医证候和免疫应激的影响研究

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目的 探讨自拟中药方辅助胆道镜双通道取石术对急性结石性胆囊炎(ACC)术后中医证候、免疫应激的影响。方法 选取2021年2月至2022年10月在上海中医药大学附属曙光医院进行治疗的ACC患者90例作为研究对象,采取随机数字表法将患者分为对照组和试验组,每组45例。所有患者均进行胆道镜手术治疗,术后对照组给予常规治疗,试验组给予常规治疗联合自拟中药方剂辅助治疗。比较两组患者治疗前后中医证候、应激反应指标[白介素(IL)-6、C反应蛋白(CRP)、血清皮质醇(Cor)和促肾上腺皮质激素(ACTH)]、T淋巴细胞亚群(CD3+、CD4+、CD4+/CD8+)和免疫球蛋白(Ig)指标(IgA、IgM、IgG)的变化。结果 两组患者术后经过不同治疗方案后,试验组患者中医证候积分、IL-6、CRP、Cor和ACTH低于对照组(P<0。05);CD3+、CD4+、CD4+/CD8+和IgA、IgM、IgG水平高于对照组(P<0。05)。结论 中药方剂辅助胆道镜双通道取石术治疗ACC可有效改善患者临床症状,提高免疫功能,加快患者康复。
Effect of Self-made Traditional Chinese Medicine Prescription on Postoperative Traditional Chinese Medicine Syndrome and Immune Stress in Patients with Acute Calculous Cholecystitis
Objective To explore the effect of self-made traditional Chinese medicine(TCM)prescription assisted dual channel choledochoscopy lithotomy on postoperative TCM syndrome and immune stress in patients with acute calculous cholecystitis(ACC).Methods A total of 90 patients with ACC who were treated in Shuguang Hospital Affiliated to Shanghai University of TCM from February 2021 to October 2022 were selected as the research objects.They were randomly divided into two groups,with 45 patients in each group.All patients underwent cholangioscopy lithotomy.After operation,the control group was given routine anti-infection and anti-inflammation treatment,while the experimental group was additionally treated with self-made TCM prescription based on the treatment in the control group.The changes in TCM syndrome,stress response indicators[interleukin(IL)-6,C-reactive protein(CRP),serum cortisol(Cor)and adrenocorticotropic hormone(ACTH)],T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+)and immunoglobulin(Ig)indicators(IgA,IgM,IgG)were compared between the two groups before and after treatment.Results After the different postoperative treatment schemes,the TCM syndrome scores and levels of stress response indicators IL-6,CRP,Cor and ACTH of patients in the experimental group were lower than those in the control group(P<0.05),while the levels of T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+)and immunoglobulin indexes(IgA,IgM,IgG)in the experimental group were higher than those in the control group(P<0.05).Conclusion TCM prescription assisted dual channel choledochoscopy lithotomy can effectively improve the clinical symptoms of patients with ACC,promote the immune function,and accelerate the recovery.

Acute calculous cholecystitisTraditional Chinese medicine prescriptionCholedochoscopeStress indicatorImmune function

陆婷、王煜、谢梦雪、姚静

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上海中医药大学附属曙光医院外科(上海 201203)

急性结石性胆囊炎 中药方剂 胆道镜 应激指标 免疫功能

2025

成都医学院学报
成都医学院

成都医学院学报

影响因子:0.933
ISSN:1674-2257
年,卷(期):2025.20(1)