Objective To explore the diagnostic value of serum levels of growth differentiation factor 15(GDF-15)and calgranulin C(S100A12)for neutropenia accompanied by fever after chemotherapy in children with acute leukemia.Methods In this study,120 acute leukemia children with neutropenia accompanied by fever after chemotherapy admitted to the Affiliated Hospital of Jining Medical University from January 2022 to January 2024 were included in the experimental group,and 138 acute leukemia children without neutropenia accompanied by fever after chemotherapy were included in the control group.Enzyme linked immunosorbent assay(ELISA)was utilized to detect the serum levels of GDF-15 and S100A12 of children in both groups.Pearson method was employed to analyze the correlation between serum GDF-15 and S100A12 levels with the clinical data of acute leukemia children with neutropenia accompanied by fever after chemotherapy.Multivariate Logistic regression was used to analyze the influencing factors of neutropenia accompanied by fever in children with acute leukemia after chemotherapy.Receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of serum GDF-15 and S100A12 levels for neutropenia accompanied by fever in children with acute leukemia after chemotherapy.Results Compared with the control group,the experimental group showed a decrease in hemoglobin(Hb),neutrophil count,white blood cell(WBC)count,and platelet count(P＜0.05),but an increase in serum GDF-15 and S100A12 levels(P＜0.05).The serum levels of GDF-15 and S100A12 were negatively correlated with Hb,neutrophil count,WBC count,and platelet count in children with neutropenia accompanied by fever(P＜0.05).Hb,neutrophil count,WBC count,and platelet count were all protective factors for neutropenia accompanied by fever in children(P＜0.05),while serum GDF-15 and S100A12 were risk factors(P＜0.05).The areas under the curve(AUCs)of serum GDF-15 and S100A12 levels for diagnosing neutropenia accompanied by fever in children with acute leukemia after chemotherapy were 0.950 and 0.907,respectively.The AUC of the combined diagnosis of the two was 0.980,which was higher than that of GDF-15(Z=2.159,P=0.031)and S100A12(Z=3.780,P=0.001)alone.Conclusion The expression levels of serum GDF-15 and S100A12 are elevated in acute leukemia children with neutropenia accompanied by fever after chemotherapy.The combination of the two has high diagnostic value for neutropenia accompanied by fever.
Pediatric acute leukemiaNeutropenia accompanied by feverGrowth differentiation factor 15Calgranulin CDiagnosis
维普
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