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超重力反溶剂沉淀法快速制备疏水药物纳米颗粒

Facile preparation of danazol nanoparticles by high-gravity anti-solvent preciditation (HGAP) method

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The nanoparticles of the hydrophobie drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti.solvent precipitation(HGAP)process.Intensified mlcromlxlng and uniform nucleation environment are created by thc high-gravity equipment(rotating packed bed)in carrymg out the anti-solvent precipitation process to produce nanoparticles.The average particle size decreases from 55μm of the raw danazol to 190 nm of the nanoparticles,The Brunauer-Emmett-Teller(BET)surface area sharply Increases from 0.66 ,m2.g-1 to 15.08 m2.g-1.Accordingly,the dissolution rate is greatly improved.The molecular state,chemical.composition,and crystal form of the danazol nanoparticles remains unchanged after processmg according to Fourier transtorm infrared(FTIR)and X-ray difiraction(XRD).The high recovery ratio and continuous production-capa-city are highly appreciated in industry.Therefore,the HGAP method might offer a general and facile platform tor mass production of hydrophobic pharmaceutical danazol particles in nanometer range.

high-gravity antisolvent precipitation,rotating packed beddanazol,nanoparticles,dissolution rate

赵宏、王洁欣、张海霞、沈志刚、甄崇礼、陈建峰

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Sin-China Nano Technology Center, key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 10029,China

Nanomaterials Technology Pte.Ltd.,Singapore

high-gravity antisolvent precipitation,rotating packed bed danazol,nanoparticles,dissolution rate

国家高技术研究发展计划(863计划)Talent Training Program of Beijing

2006AA03020220078022

2009

中国化学工程学报(英文版)
中国化工学会

中国化学工程学报(英文版)

CSTPCDCSCDSCIEI
影响因子：0.818
ISSN：1004-9541
年,卷(期)：2009.17(2)
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