首页|Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering emulsions.However,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surpris-ingly sparse.This gap in knowledge holds significant potential for enhancing vaccine efficacy.This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue.The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study.Various factors impacting the transport process are explored,including local cellular tissue environ-mental factors and the properties of the Pickering emulsion itself.The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency.Additionally,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel.This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions.Such insights hold valu-able potential for optimizing transport processes in practical biomedical applications such as drug de-livery.Importantly,the desired transport efficiency varies depending on the specific application.For instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

Pickering emulsionSkeletal muscular cellsTransport phenomenaDissipative particle dynamicsDrug delivery

Xuwei Liu、Wei Chen、Yufei Xia、Guanghui Ma、Reiji Noda、Wei Ge

展开 >

State Key Laboratory of Mesoscience and Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China

Division of Environmental Engineering Science,Graduate School of Science and Technology,Gunma University,1-5-1 Tenjin-cho,Kiryu,Gunma 376-8515,Japan

School of Chemical Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

Innovation Academy for Green Manufacture,Chinese Academy of Sciences,Beijing 100190,China

State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China

展开 >

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience Fund for Creative Research Groups of the National Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaDistinguished Young Scholars of the National Natural Science Foundation of China

2237310422293024218210052021YFE020527T2222022

2024

10.1016/j.cjche.2024.01.002

中国化学工程学报(英文版)
中国化工学会

中国化学工程学报(英文版)

CSTPCDEI
影响因子：0.818
ISSN：1004-9541
年,卷(期)：2024.68(4)
  • 57