首页|Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy
Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy
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The key factor in photothermal therapy lies in the selection of photothermal agents.Traditional pho-tothermal agents generally have problems such as poor photothermal stability and low photothermal conversion efficiency.Herein,we have designed and synthesized an isoindigo(IID)dye.We used iso-indigo as the molecular center and introduced common triphenylamine and methoxy groups as rotors.In order to improve the photothermal stability and tumor targeting ability,we encapsulated IID into nanoparticles.As a result,the nanoparticles exhibited high photothermal stability and photothermal conversion efficiency(67％)upon 635 nm laser irradiation.Thus,the nanoparticles demonstrated a significant inhibitory effect on live tumors in photothermal therapy guided by photoacoustic imaging and provided a viable strategy to overcome the treatment challenges.
State Key Laboratory of Fine Chemicals,Frontiers Science Center for Smart Materials Oriented Chemical Engineering,Dalian University of Technology,Dalian 116024,China
Ningbo Institute of Dalian University of Technology,Ningbo 315016,China
State Key Laboratory of Fine Chemicals,Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology,Dalian 116024,China
National Natural Science Foundation of ChinaFundamental Research Fundamental Funds for the Central UniversitiesLiaoning Binhai LaboratoryChina Postdoctoral Science Foundation
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