Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy

Yao Pei ¹Ran Wang ¹Xiang Rong ¹Xiang Xia ²Hexiang Wang ¹Zongwei Zhang ¹Tian Qiu ¹Saran Long ³Jianjun Du ³Jiangli Fan ³Wen Sun ³Xiaojun Peng¹

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作者信息

1. State Key Laboratory of Fine Chemicals,Frontiers Science Center for Smart Materials Oriented Chemical Engineering,Dalian University of Technology,Dalian 116024,China
2. Ningbo Institute of Dalian University of Technology,Ningbo 315016,China
3. State Key Laboratory of Fine Chemicals,Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology,Dalian 116024,China;Ningbo Institute of Dalian University of Technology,Ningbo 315016,China
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Abstract

The key factor in photothermal therapy lies in the selection of photothermal agents.Traditional pho-tothermal agents generally have problems such as poor photothermal stability and low photothermal conversion efficiency.Herein,we have designed and synthesized an isoindigo(IID)dye.We used iso-indigo as the molecular center and introduced common triphenylamine and methoxy groups as rotors.In order to improve the photothermal stability and tumor targeting ability,we encapsulated IID into nanoparticles.As a result,the nanoparticles exhibited high photothermal stability and photothermal conversion efficiency(67％)upon 635 nm laser irradiation.Thus,the nanoparticles demonstrated a significant inhibitory effect on live tumors in photothermal therapy guided by photoacoustic imaging and provided a viable strategy to overcome the treatment challenges.

Key words

Photothermal therapy/Isoindigo/Nanoparticles/Photoacoustic imaging

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基金项目

National Natural Science Foundation of China(22078046)

Fundamental Research Fundamental Funds for the Central Universities(DUT22LAB601)

Liaoning Binhai Laboratory(LBLB-2023-03)

China Postdoctoral Science Foundation(2023M740487)

出版年

2024

中国化学工程学报(英文版)

中国化工学会

中国化学工程学报(英文版)

CSTPCDEI

影响因子：0.818

ISSN：1004-9541

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