首页|Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures:Experimental measurements and thermodynamic modeling

Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures:Experimental measurements and thermodynamic modeling

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The equilibrium solubility of Rebaudioside A(Reb A)Form Ⅱ in binary mixtures of methanol/ethanol and ethyl acetate was quantitatively determined within the temperature range of 283.15-328.15 K at ambient pressure.The experimental findings indicate a positive correlation between the solubility of Reb A(Form Ⅱ)and both the temperature and the methanol/ethanol content in the solvent system.To describe the solubility data,six distinct models were employed:the modified Apelblat equation,the λh model,the combined nearly ideal binary solvent/Redlich-Kister(CNIBS/R-K)model,the van't Hoff-Jouyban-Acree(VJA)model,the Apelblat-Jouyban-Acree(AJA)model,and the non-random two-liquid(NRTL)model.The combined nearly ideal binary solvent/Redlich-Kister model exhibited the most precise fit for solubility in methanol+ethyl acetate mixtures,reflected by an average relative deviation(ARD)of 0.0011 and a root mean square deviation(RMSD)of 12 ×10-7.Conversely,for ethanol+ethyl acetate mixtures,the modified Apelblat equation provided a superior correlation(ARD=0.0014,RMSD=4×10-7).Furthermore,thermodynamic parameters associated with the dissolution of Reb A(Form Ⅱ),including enthalpy,entropy,and the Gibbs energy change,were inferred from the data.The findings underscore that the dissolution process is predominantly endothermic across the solvent sys-tems examined.Notably,the entropy changes appear to have a significant influence on the Gibbs free energy associated with the dissolution of Reb A(Form Ⅱ),suggesting that entropic factors may play a pivotal role in the studied systems.

Rebaudioside ASolubilityThermodynamic modelingDissolutionBinary solvent

Zhenguang Liu、Zexiang Ding、Yifeng Cao、Baojian Liu、Qiwei Yang、Zhiguo Zhang、Qilong Ren、Zongbi Bao

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Key Laboratory of Biomass Chemical Engineering of Ministry of Education,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310058,China

Institute of Zhejiang University-Quzhou,Quzhou 324000,China

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaResearch Funds of Institute of Zhejiang University-QuzhouResearch Funds of Institute of Zhejiang University-Quzhou

2021YFC2103800U21A20301IZQ2022RCZX004IZQ2021RCZX015

2024

10.1016/j.cjche.2024.05.020

中国化学工程学报(英文版)
中国化工学会

中国化学工程学报(英文版)

CSTPCDEI
影响因子：0.818
ISSN：1004-9541
年,卷(期)：2024.72(8)