首页|One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM)in Water

One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM)in Water

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Copper(0)-mediated reversible-deactivation radical polymerization(Cu(0)-mediated RDRP)of the water-soluble monomer N-isopropylacrylamide(NIPAM)has been challenging with the problems of high dispersity,poor control over the molecular weights(MWs)or complex or multi reaction steps,etc.In this work,we report the well-controlled polymerization of NIPAM in water via a facile one-pot and one-step Cu(0)-mediated RDRP.The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient CuⅠ at the very beginning,and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process.For NIPAM,which has a high propagation rate constant,the deactivation control can be effectively enhanced by extra adding deactivator(i.e.,CuⅡ)to the system.Moreover,a low reaction temperature(4 ℃)is necessary in the controlled synthesis of higher MW poly(N-isopropylacrylamide)(PNIPAM)to avoid the compromise in control caused by the phase transition from its lower critical solution temperature(LCST).Through this new kinetically controlled strategy,PNIPAMs with well-defined structure,narrow molecular weight distributions(MWDs)and varied MWs were successfully achieved.

Cu(0)-mediated RDRPN-isopropylacrylamidePropagationDeactivationReaction parameters

Zi-Shan Li、Jing Lyu、Bei Qiu、Ying-Hao Li、Ruth Foley、Ri-Jian Song、Melissa Johnson、Qiang Geng、Wen-Xin Wang

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Institute of Precision Medicine(AUST-IPM),Anhui University of Science and Technology,Huainan 232001,China

Charles Institute of Dermatology,School of Medicine,University College Dublin,Dublin D04 V1W8,Ireland

Science Foundation Ireland(SFI)Frontiers for the Future call(2019)国家自然科学基金Irish Research Council(IRC)Government of Ireland Postdoctoral Fellowship

19/FFP/652251873179GOIPD/2022/209

2024

10.1007/s10118-024-3065-0

高分子科学(英文版)
中国化学会　中国科学院化学研究所

高分子科学(英文版)

CSTPCD
影响因子：0.721
ISSN：0256-7679
年,卷(期)：2024.42(1)
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