首页|pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging
pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging
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This work reported an AIE fluorescent probe for tumor imaging based on the pH induced self-assembly strategy.The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-b-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen(AIEgen)TPE-2SO3-.The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment,which would be further self-assembled with TPE-2SO3-to form aggregated nanoparticles.The transition of TPE-2SO3-from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.
NETL
NSTL
万方数据
维普
