首页|Thermo-and pH-sensitive Polymer with Pendant Spacer-linked Imidazole Cycles
Thermo-and pH-sensitive Polymer with Pendant Spacer-linked Imidazole Cycles
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By the reaction of poly(acryloyl chloride)with N-(3-aminopropyl)imidazole,poly(N-(3-(1H-imidazol-1-yl)propyl)acrylamide)was syn-thesized.The new polymer contains an imidazole ring removed from the main chain by a spacer of five bonds.The structure and purity,molecu-lar weight,hydrodynamic and thermosensitive properties of the obtained sample were studied by1H-and 13C-NMR,FTIR spectroscopy,acid-base titration,light scattering,turbidimetry and viscometry.The observed ability of the imidazole-containing polymer to form and destroy associates in water-salt solutions at pH 6.6-7.4 and temperatures of 29-48 ℃ indicates that these are promising candidates for designing complex biomedi-cal systems.The new polymer is able to form complexes with oligo-DNA more actively than poly(1-vinylimidazole),which is of interest for gene delivery applications.The polymer cross-linked with epichlorohydrin gives micro-relief coatings on the plastic surface,and the modified surface is able to attach negatively charged objects.This thermo-and pH-sensitive polymer modification can be applied to create finely controlled surfaces for cell culturing.
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