首页|Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

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L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from biomass.The present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild conditions.PLTDs with molar masses up to 8500 g/mol and high yields exceeding 90％are obtained.The chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spec-troscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation method.Upon light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst re-lease of 80％cargo within 13 s.Furthermore,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and af-ter irradiation.Overall,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,signifi-cantly simplifying the synthetic pathway of light-responsive polymers.

L-glutamic acidPasserini three-component polymerizationLight-responsivePolyesterNanoparticles

Xiao-Fei Sun、Xu Zhang、Shu-Ping Song、Ya-Qun Yao、Yan Zhang、Cheng-Liang Wang、Jing-Jiang Sun、Qing-Fu Wang

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Key Laboratory of Rubber-plastics,Ministry of Education,School of Polymer Science and Engineering,Qingdao University of Science and Technology,Qingdao 266042,China

Qingdao Research Academy of Environmental Science,Qingdao 266012,China

International Science and Technology Assistance Program of the Ministry of Science and TechnologyShandong Provincial Natural Science Foundation Magnitude Fundamental Research,ChinaQingdao New Energy Shandong Laboratory Open Project

KY202001016ZR2022ZD11QNESL OP202312

2024

10.1007/s10118-024-3093-9

高分子科学(英文版)
中国化学会　中国科学院化学研究所

高分子科学(英文版)

CSTPCD
影响因子：0.721
ISSN：0256-7679
年,卷(期)：2024.42(5)