首页|Unconventional Fluorescent and Multi-responsive Polysiloxane:Synthesis,Characterization and Biological Applications

Unconventional Fluorescent and Multi-responsive Polysiloxane:Synthesis,Characterization and Biological Applications

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Owing to their high significance in fundamental study and diverse applications,stimuli-responsive and fluorescent polymers,particu-larly those with cluster-triggered emission(CTE)featured by non-conjugated chromophores,have drawn tremendous attention in recent years.In this work,fluorescent and multi-responsive polysiloxane(FRPS)was synthesized by hydrolytic condensation polymerization of 3-aminopropyl methyl diethoxysilane(APMS)with 3-(N-isopropyl propionamide)iminopropyl methyl diethoxysilane(APMS-NIP),which was formed in situ through aza-Michael addition between APMS and N-isopropyl acrylamide.FRPS was not only highly sensitive to temperature,pH and CO2 in wa-ter,but also showed an enhanced and stimuli-adjustable fluorescence emission.The effects of monomer feeding,pH and CO2 on its lower critical solution temperature and fluorescent property were investigated.FRPS fluorescence emission was ascribed to CTE mechanism.In addition,FRPS was shown to be highly potential as physiological indicator for cell imaging,and for controlled release and trace detection of doxorubicin.This study provides therefore a type of stimuli-responsive and fluorescent material for potential applications in biomedical fields,and it is also of great significance for understanding of the fluorescence mechanism of polysiloxane-based stimuli-responsive polymers.

PolysiloxaneMulti-responsivenessCluster-triggered emissionCell imagingControlled drug release

Xiao-Di Li、Shu-Sheng Li、Xu-Bao Jiang、Xiao-Li Zhu、Xiang Zheng Kong

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College of Chemistry and Chemical Engineering,University of Jinan,Jinan 250022,China

College of Chemical Engineering,Tianjin University,Tianjin 300072,China

Foshan(Southern China)Institute for New Materials,Foshan 528200,China

Nature Science Foundation of Shandong Province,ChinaNature Science Foundation of Shandong Province,ChinaScience and Technology Bureau of Jinan City中国博士后科学基金Basic and Applied Basic Research Foundation of Guangdong Province,China

ZR2021MB112ZR2022MB0512021GXRC1052022M7123432020A1515110374

2024

10.1007/s10118-024-3091-y

高分子科学(英文版)
中国化学会　中国科学院化学研究所

高分子科学(英文版)

CSTPCD
影响因子：0.721
ISSN：0256-7679
年,卷(期)：2024.42(5)