Abstract
Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative nanomedicines.In this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery platform.The micelles were created using an amphiphilic block polymer synthesized via ring-opening poly-merization of e-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial biofilms.An important advantage of our mi-celles lies in their interaction with local bacterial lipases within biofilms.These lipases triggered rapid micelle degradation,releasing triclosan in a controlled manner.This liberated triclosan effectively eliminated bacteria embedded in the biofilms.Notably,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and safety.This finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial biofilms.Our triclosan-conjugated,lipase-responsive polymeric micelles ex-hibit promising characteristics for addressing drug resistance in bacterial biofilms.By harnessing biofilm properties and implementing a respon-sive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.
基金项目
国家自然科学基金(22275043)
国家自然科学基金(52203184)
国家自然科学基金(52293380)
国家自然科学基金(52293383)
Startup Fund of Wenzhou Institute,University of Chinese Academy of Sciences(WIUCASQD2021022)
Startup Fund of Wenzhou Institute,University of Chinese Academy of Sciences(WIUCASQD2021019)
维普
万方数据