首页|Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms
Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms
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Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative nanomedicines.In this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery platform.The micelles were created using an amphiphilic block polymer synthesized via ring-opening poly-merization of e-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial biofilms.An important advantage of our mi-celles lies in their interaction with local bacterial lipases within biofilms.These lipases triggered rapid micelle degradation,releasing triclosan in a controlled manner.This liberated triclosan effectively eliminated bacteria embedded in the biofilms.Notably,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and safety.This finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial biofilms.Our triclosan-conjugated,lipase-responsive polymeric micelles ex-hibit promising characteristics for addressing drug resistance in bacterial biofilms.By harnessing biofilm properties and implementing a respon-sive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.
Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance,Youjiang Medical University for Nationalities,Baise533000,China
Translational Medicine Laboratory,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325035,China
Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China
State Key Laboratory of Medicinal Chemical Biology,Key Laboratory of Functional Polymer Materials of Ministry of Education,and Institute of Polymer Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China
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国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Startup Fund of Wenzhou Institute,University of Chinese Academy of SciencesStartup Fund of Wenzhou Institute,University of Chinese Academy of Sciences
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