Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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外文摘要：Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent years.However,the underlying interaction between their fluorescent properties and phase transi-tion remains unclear.In this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by re-acting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as pH.Notably,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence emission.We further investigated the effects of NIPAM grafting per-centage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous solutions.Moreover,we show-cased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of doxorubicin.Our study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

外文关键词：

PolyethyleneimineMulti-responsivenessIntrinsic fluorescence emissionCell imagingControlled drug release

作者：

Feng-Ming Yin、Li-Li Wu、Shu-Sheng Li、Xiao-Na Pan、Xiao-Li Zhu、Xu-Bao Jiang、Xiang Zheng Kong

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作者单位：

College of Chemistry and Chemical Engineering,University of Jinan,Jinan 250022,China

Shandong Institute for Product Quality Inspection,Jinan 250102,China

College of Chemical Engineering,Tianjin University Tianjin 300072,China

基金：

Nature Science Foundation of Shandong Province,ChinaNature Science Foundation of Shandong Province,ChinaScience and Technology Bureau of Jinan City中国博士后科学基金Basic and Applied Basic Research Foundation of Guangdong Province,China

项目编号：

ZR2021MB112ZR2022MB0512021GXRC1052022M7123432020A1515110374

出版年：

2024

DOI：

10.1007/s10118-024-3120-x

高分子科学(英文版)

中国化学会　中国科学院化学研究所

高分子科学(英文版)

CSTPCD

影响因子：0.721

ISSN：0256-7679

年,卷(期)：2024.42(6)