Photoswitchable Spiropyridine Enabled Photoactuation of Polymeric Hydrogels under Physiological pH Conditions

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外文摘要：The incorporation of molecular switches into polymer networks has been a powerful approach for the development of functional poly-mer materials that display macroscopic actuation and function enabled directly by molecular changes.However,such materials sometimes re-quire harsh conditions to perform their functions,and the design of new molecular photoswitches that can function under physiological condi-tions is highly needed.Here,we report the design and synthesis of a spiropyridine-based photoswitchable hydrogel that exhibits light-driven ac-tuation at physiological pH.Owing to its high pKa,spiropyridine maintains its ring-open protonated form at neutral pH,and the resulting hydro-gel remains in a swollen state.Upon irradiation with visible light,the ring closure of spiropyridine leads to a decrease in the charge and a reduc-tion in the volume of the hydrogel.The contracted gel could spontaneously recover to its expanding state in the dark,and this process is highly dynamic and reversible when the light is switched on and off.Furthermore,the hydrogel shows switchable fluorescence in response to visible light.Bending deformation is observed in the hydrogel thin films upon irradiation from one side.Importantly,the independence of this spiropyri-dine hydrogel from the acidic environment makes it biotolerant and shows excellent biocompatibility.This biocompatible spiropyridine hydro-gel might have important biorelated applications in the future.

外文关键词：

Spiropyridine photowitchPolymer hydrogelPhotoactuationPhysiological pHBiocompatibility

作者：

Cong Liao、Meng-Qi Du、Chuang Li

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作者单位：

Key Laboratory of Precision and Intelligent Chemistry,Department of Polymer Science and Engineering,University of Science and Technology of China,Hefei 230026,China

基金：

National Natural Science Foundation of ChinaNational Key R&D Program of ChinaNatural Science Foundation of Anhui Province

项目编号：

523731212022YFA13051002208085MB27

出版年：

2024

DOI：

10.1007/s10118-024-3211-8

高分子科学(英文版)

中国化学会　中国科学院化学研究所

高分子科学(英文版)

CSTPCD

影响因子：0.721

ISSN：0256-7679

年,卷(期)：2024.42(10)