Abstract
Photodynamic therapy(PDT)has been emerged as a promising modality for cancer treatment.However,the development of drug de-livery system enabling continuous release of photosensitizers(PSs)for long-term PDT treatment still remains challenges.Herein,a H2O2-respon-sive injectable hydrogel,covalently crosslinked by N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1,N1,N3,N3-tetramethylpropane-1,3-diaminium(TSPBA)with PVA containing polythiophene quaternary ammonium salt(PT2)polymer dots(PDots)as a photosensitizer was fabricated.Under the stimulation of H2O2,the obtained injectable hydrogel gradually degrades and releases PDots.In vitro experiments suggested that the re-leased PDots could realize efficient tumor cells inhibition through its robust singlet oxygen generation capability upon 577 nm laser irradiation.In vivo studies demonstrated a sustained retention of PDots for at least 7 days following single-dose administration,facilitating efficient tumor inhi-bition with light treatments for 3 times without apparent biotoxicity.This work presents an innovative polymer dots-based composite local drug delivery system for long-term PDT in cancer treatment.
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