首页|H2O2-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors
H2O2-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
万方数据
Photodynamic therapy(PDT)has been emerged as a promising modality for cancer treatment.However,the development of drug de-livery system enabling continuous release of photosensitizers(PSs)for long-term PDT treatment still remains challenges.Herein,a H2O2-respon-sive injectable hydrogel,covalently crosslinked by N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1,N1,N3,N3-tetramethylpropane-1,3-diaminium(TSPBA)with PVA containing polythiophene quaternary ammonium salt(PT2)polymer dots(PDots)as a photosensitizer was fabricated.Under the stimulation of H2O2,the obtained injectable hydrogel gradually degrades and releases PDots.In vitro experiments suggested that the re-leased PDots could realize efficient tumor cells inhibition through its robust singlet oxygen generation capability upon 577 nm laser irradiation.In vivo studies demonstrated a sustained retention of PDots for at least 7 days following single-dose administration,facilitating efficient tumor inhi-bition with light treatments for 3 times without apparent biotoxicity.This work presents an innovative polymer dots-based composite local drug delivery system for long-term PDT in cancer treatment.
Jian Wang、Ke Liang、Jian Li、Yun-Xiu Zhang、Xiao-Kuang Xue、Tie-Jin Chen、Yong-Liang Hao、Jia-Sheng Wu、Jie-Chao Ge
展开 >
Key Laboratory of Photochemical Conversion and Optoelectronic Materials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China
School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,China
万方数据
