材料科学技术(英文版)2021，Vol.68Issue(9) ：76-90.

Biodegradable Zn-3Cu and Zn-3Cu-0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications

Jixing Lin Xian Tong Kun Wang Zimu Shi Yuncang Li Matthew Dargusch Cuie Wen
材料科学技术(英文版)2021，Vol.68Issue(9) ：76-90.
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Biodegradable Zn-3Cu and Zn-3Cu-0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications

Jixing Lin 1Xian Tong 2Kun Wang 1Zimu Shi 3Yuncang Li 4Matthew Dargusch 5Cuie Wen4
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作者信息

  • 1. Department of Material Engineering, Zhejiang Industry (&) Trade Vocational College, Wenzhou, 325003, China
  • 2. Department of Material Engineering, Zhejiang Industry (&) Trade Vocational College, Wenzhou, 325003, China;School of Materials Science and Engineering, Xiangtan University, Xiangtan, 411105, China
  • 3. Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, China
  • 4. School of Engineering, RMIT University, Melbourne, Victoria, 3001, Australia
  • 5. Centre for Advanced Materials Processing and Manufacturing (AMPAM), The University of Queensland, Brisbane, Queensland, 4072, Australia
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Abstract

Zinc (Zn) and its alloys have been proposed as biodegradable implant materials due to their unique combination of biodegradability,biocompatibility,and biofunctionality.However,the insufficient mechanical properties of pure Zn greatly limit its clinical application.Here,we report on the microstructure,mechanical properties,friction and wear behavior,corrosion and degradation properties,hemocompatibility,and cytocompatibility of Zn-3Cu and Zn-3Cu-0.2Ti alloys under three different conditions of as-cast (AC),hot-rolling (HR),and hot-rolling plus cold-rolling (HR + CR).The HR + CR Zn-3Cu-0.2Ti exhibited the best set of comprehensive properties among all the alloy samples,with yield strength of 211.0 MPa,ultimate strength of 271.1 MPa,and elongation of 72.1 ％.Immersion tests of the Zn-3Cu and Zn-3Cu-0.2Ti alloys in Hanks' solution for 3 months indicated that the AC samples showed the lowest degradation rate,followed by the HR samples,and then the HR + CR samples,while the HR + CR Zn-3Cu exhibited the highest degradation rate of 23.9 μm/a.Friction and wear testing of the Zn-3Cu and Zn-3Cu-0.2Ti alloys in Hanks' solution indicated that the AC samples showed the highest wear resistance,followed by the HR samples,and then the HR + CR samples,while the AC Zn-3Cu-0.2Ti showed the highest wear resistance.The diluted extracts of HR + CR Zn-3Cu and Zn-3Cu-0.2Ti at a concentration of ≤25 ％ exhibited non-cytotoxicity.Furthermore,both the HR + CR Zn-3Cu and Zn-3Cu-0.2Ti exhibited effective antibacterial properties against S.aureus.

Key words

Cytotoxicity/Degradation behavior/Mechanical properties/Zn-Cu biodegradable metals

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基金项目

This work was supported financially by the Research Funds of the Wenzhou Science and Technology Bureau(ZG2019022)

This work was supported financially by the Research Funds of the Wenzhou Science and Technology Bureau(2018ZG008)

C.Wen and Y.C.Li acknowledge the support for this research by the Australian Research Council (ARC) through the Discovery Projec(DP170102557)

Future Fellowship(FT160100252)

M.Dargusch and C.Wen also acknowledge the support of the ARC Research Hub for Advanced Manufacturing of Medical Devices(IH150100024)

出版年

2021
材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCDCSCDSCI
影响因子：0.657
ISSN：1005-0302
参考文献量103
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