Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing

Wencheng Liang ¹Mingli Jiang ²Junyong Zhang ³Xiaoming Dou ⁴Yan Zhou ²Yun Jiang ⁵Li Zhao ⁶Meidong Lang³

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作者信息

1. Center of Photonics &Bio-Medical Diagnosis,School of Science,East China University of Science and Technology,Shanghai 200237,China;Shanghai Key Laboratory of Advanced Polymeric Materials,Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China
2. State Key Laboratory of Bioreactor Engineering,School of Biotechnology,East China University of Science and Technology,Shanghai 200237,China
3. Shanghai Key Laboratory of Advanced Polymeric Materials,Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China
4. Center of Photonics &Bio-Medical Diagnosis,School of Science,East China University of Science and Technology,Shanghai 200237,China
5. The Library of Zhejiang University of Technology,Zhejiang University of Technology,Hangzhou 310023,China
6. State Key Laboratory of Bioreactor Engineering,New World Institute of Biotechnology,East China University of Science and Technology,Shanghai 200237,China
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Abstract

In this work,novel antibacterial cellulose diacetate/poly(ethylenimine)/hyaluronic acid (CDA/PEI/HA)composite three-dimension (3D) scaffolds were prepared through electrospinning and post-processing.Firstly,CDA/PEI 2D composite nanofiber membranes were prepared by electrospinning,and then the CDA/PEI/HA 3D composite scaffolds were fabricated by post-processing and freeze-drying of CDA/PEI membranes.In particular,HA was added to improve the biocompatibility of composite scaffolds.Com-pared with CDA/PEI scaffolds,CDA/PEI/HA composite scaffolds showed higher water absorbing rate,higher water retention rate and higher mechanical strength.Moreover,CDA/PEI/HA composite scaffolds with abundant positive charge were benefit for improving antibacterial activity.CDA/PEI/HA scaffolds with biology function of HA were benefit for improving hemocompatibility and cell proliferation of CDA/PEI scaffolds.In summary,antibacterial CDA/PEI/HA scaffolds could protect wound from bacterial infection,improve cellular behavior and accelerate wound healing.Thus,CDA/PEI/HA scaffolds could be potential application for wound dressing.

Key words

Cellulose diacetate/Electrospinning/3D scaffold/Wound dressing

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基金项目

National Key Research and Development Program(2016YFC1100703)

Research Center of Analysis and Test of East China University of Science and Technology for the help in characterization()

出版年

2021

材料科学技术(英文版)

中国金属学会中国材料研究学会中国科学院金属研究所

材料科学技术(英文版)

CSTPCDCSCDSCI

影响因子：0.657

ISSN：1005-0302

被引量1

参考文献量44

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