Biomaterials based cardiac patches for the treatment of myocardial infarction

Tianqi Chang ¹Chunxia Liu ²Kunyan Lu ³Yong Wu ²Mingzhu Xu ⁴Qian Yu ³Zhenya Shen ²Tingbo Jiang ⁴Yanxia Zhang²

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作者信息

1. Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science,Soochow University,Suzhou 215006,China;Department of Cardiology,The First Affiliated Hospital of Soochow University,Suzhou 215006,China
2. Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science,Soochow University,Suzhou 215006,China
3. state and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China
4. Department of Cardiology,The First Affiliated Hospital of Soochow University,Suzhou 215006,China
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Abstract

Myocardial infarction (MI) is one of the common cardiovascular diseases that occurs with a blockage in one or more of the coronary arteries to lead to the damage of the myocardium,resulting in a life-threatening condition.To repair the damaged myocardium in MI,researchers are looking forwards to new ways to postpone the progression of myocardial injury.Cardiac patches,the scaffolds layered on the heart surface,can provide mechanical support for the infarction site and improve cardiac function by delivering various bioactive factors or cells,showing considerable curative effect in the treatment of MI.Biomate-rials with certain biocompatibility and mechanical properties have received widespread attention for the application in cardiac patches.In this review,we focus on the recent progress on these biomaterials-based cardiac patches,which could be categorized into two types according to the sources of materials including (i) natural materials and (ii) synthetic materials.The major advantages and current challenges of each type are discussed and a brief perspective on the future research directions is presented.

Key words

Biomaterials/Cardiac patches/Myocardial infarction

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基金项目

National Natural Science Foundation of China(91839101)

National Natural Science Foundation of China(21774086)

Natural Science Foundation of Jiangsu Province(BK20180093)

Suzhou Mu-nicipal Science and Technology Foundation(SYS2018026)

Introduction Project of Clinical Medicine Expert Team for Suzhou(SZYJTD201704)

Project of Improvement in Clinical Trial Ability of Cardiovascular Group of the First Affiliated Hospital of Soochow Univers(201900180019)

Application Research on New Platelet Function-detecting Technology in Thrombosis Pre-vention(31010303010982)

Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)()

出版年

2021

材料科学技术(英文版)

中国金属学会中国材料研究学会中国科学院金属研究所

材料科学技术(英文版)

CSTPCDCSCDSCI

影响因子：0.657

ISSN：1005-0302

被引量1

参考文献量160

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