材料科学技术(英文版)2021,Vol.95Issue(36) :237-248.

Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys

Ling Ren Xiaohe Xu Hui Liu Ke Yang Xun Qi
材料科学技术(英文版)2021,Vol.95Issue(36) :237-248.

Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys

Ling Ren 1Xiaohe Xu 2Hui Liu 3Ke Yang 1Xun Qi4
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作者信息

  • 1. Shi-changxu Innovation Center for Advanced Materials,Institute of Metal Research,Chinese Academy of Sciences,72 Wenhua Road,Shenyang 110016,China
  • 2. Department of Ophthalmology,Shengjing Hospital of China Medical University,36 Sanhao Street,Shenyang 110001,China
  • 3. Shi-changxu Innovation Center for Advanced Materials,Institute of Metal Research,Chinese Academy of Sciences,72 Wenhua Road,Shenyang 110016,China;School of Materials Science and Engineering,University of Science and Technology of China,96 Jinzhai Road,Hefei 230026,China
  • 4. Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province,Department of Radiology,The First Affiliated Hospital of China Medical University,155 Nanjing Bei Street,Shenyang 110001,China
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Abstract

To reduce the risk of implant-associated infections,we previously designed and developed a series of medical copper (Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial role.However,both excessive and deficient Cu levels adversely affect human health;therefore,the aim of the present study was to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys (Ti6Al4V-Cu and Ti-Cu) both in vitro and in vivo.Moreover,the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also investigated.The results indicate that the biocompat-ibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release rate.The release rate maintained at a parts per billion level safe for humans;consequently,we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility.

Key words

Cu ions/Kinetic/Biocompatibility/Titanium

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基金项目

National Key Research and De-velopment Program of China(2018YFC1106600)

National Key Research and De-velopment Program of China(2016YFC1100600)

LiaoNing Revitalization Talents Program(XLYC1807069)

National Natural Science Foundation(51631009)

National Natural Science Foundation(31870954)

National Natural Science Foundation(81873918)

Startup Fundation for Docotors of Liaoning Province(2019-BS-293)

出版年

2021
材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCDCSCDSCI
影响因子:0.657
ISSN:1005-0302
参考文献量34
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