Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys

Ling Ren ¹Xiaohe Xu ²Hui Liu ³Ke Yang ¹Xun Qi⁴

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作者信息

1. Shi-changxu Innovation Center for Advanced Materials,Institute of Metal Research,Chinese Academy of Sciences,72 Wenhua Road,Shenyang 110016,China
2. Department of Ophthalmology,Shengjing Hospital of China Medical University,36 Sanhao Street,Shenyang 110001,China
3. Shi-changxu Innovation Center for Advanced Materials,Institute of Metal Research,Chinese Academy of Sciences,72 Wenhua Road,Shenyang 110016,China;School of Materials Science and Engineering,University of Science and Technology of China,96 Jinzhai Road,Hefei 230026,China
4. Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province,Department of Radiology,The First Affiliated Hospital of China Medical University,155 Nanjing Bei Street,Shenyang 110001,China
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Abstract

To reduce the risk of implant-associated infections,we previously designed and developed a series of medical copper (Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial role.However,both excessive and deficient Cu levels adversely affect human health;therefore,the aim of the present study was to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys (Ti6Al4V-Cu and Ti-Cu) both in vitro and in vivo.Moreover,the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also investigated.The results indicate that the biocompat-ibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release rate.The release rate maintained at a parts per billion level safe for humans;consequently,we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility.

Key words

Cu ions/Kinetic/Biocompatibility/Titanium

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基金项目

National Key Research and De-velopment Program of China(2018YFC1106600)

National Key Research and De-velopment Program of China(2016YFC1100600)

LiaoNing Revitalization Talents Program(XLYC1807069)

National Natural Science Foundation(51631009)

National Natural Science Foundation(31870954)

National Natural Science Foundation(81873918)

Startup Fundation for Docotors of Liaoning Province(2019-BS-293)

出版年

2021

材料科学技术(英文版)

中国金属学会中国材料研究学会中国科学院金属研究所

材料科学技术(英文版)

CSTPCDCSCDSCI

影响因子：0.657

ISSN：1005-0302

参考文献量34

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