Abstract
Magnesium(Mg)alloys can be regarded as the most promising biodegradable implant materials for or-thopedic and stent applications due to their good biocompatibility and low Young's modulus which is near to that of natural bone.However,its applicability is hindered because it exhibits a high corrosion rate in the physiological environments.In this work,we fabricated Mg66Zn30Ca4/Fe bulk metallic glass composites via spark plasma sintering(SPS).We studied the influence of different contents of Fe on the properties of the composites.The results indicated that Fe was uniformly distributed on the surface of Mg66Zn30Ca4 metallic glass(MG)as a second phase,which led to an improvement in the corrosion re-sistance and mechanical strength.The standard potential of Mg66Zn30Ca4/Fe bulk metallic glass(BMG)composites increased as compared to Mg66Zn30Ca4,while their mechanical strength improved from 355 MPa to 616 MPa.Furthermore,cytotoxicity was investigated via the CCK-8 assay and calcein-AM stain-ing,which revealed that the extraction mediums diluted 6 times(EM×6)of the Mg66Zn30Ca4 and Mg66Zn30Ca4/Fe did not cause cell toxicity on day 3 and 5,while the EM×6 of the Mg66Zn30Ca4 showed cytotoxicity on day 1,3 and 5.Thus,Mg66Zn30Ca4/Fe BMG composites exhibit significant potential for fabricating implants with good mechanical strength and corrosion resistance.
基金项目
Shenzhen Knowl-edge Innovation Plan-Fundamental ResearchDiscipline Distri-bution(JCYJ20180507184623297)
National Natural Sci-ence Foundation of China(51871077)
National Natural Sci-ence Foundation of China(51771233)
Shenzhen Science and Technology Plan-Technology Innovation(KQJSCX20180328165656256)
Startup Foundation from Shen-zhen and Startup Foundation from Harbin Institute of Technology Shenzhen()
Development and Reform Commission of Shenzhen Municipality-Shenzhen R&D Center for Al-based Hydrogen Hydrol-ysis Materials(ZX20190229)
NETL
NSTL
维普
万方数据