Abstract
Bacterial cellulose(BC)is one of the most versatile natural biopolymers with unique physical,chemical,and biological features.However,the lack of intrinsic antibacterial property of native BC limits its broad biomedical applications where such property is highly required to prevent contamination or infection caused by attached bacteria.In this work,we developed a simple and facile method to fabricate a dual-functional BC membrane by physical incorporation of gold nanorods(GNRs)followed by deposition of a phase-transitioned bovine serum albumin(PTB)film.Due to the broad-spectrum antifouling property of the PTB film,the resulting membrane could prevent the adhesion and accumulation of bacteria.A few bacteria that broke through the protection of the PTB film could be eradicated under short-term irradia-tion of a near-infrared laser due to the excellent photothermal property of incorporated GNRs.The whole fabrication was conducted in a simple and environmentally friendly manner,avoiding complicated pro-cesses and toxic organic solvents.Moreover,because all the components were biocompatible,the result-ing membrane showed negligible cytotoxicity in vitro and good histocompatibility in vivo.This work thus provided a reliable way to endow BC with antibacterial property,being beneficial for diverse biomedical applications.
基金项目
国家自然科学基金(21774086)
国家自然科学基金(22175125)
江苏省自然科学基金(BK20180093)
Natural Science Foundation of the Jiangsu Higher Education In-stitutions of China(21KJA150008)
Suzhou Municipal Science and Technology Foundation(SYS2018026)
维普
万方数据